The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein

BACKGROUND: Myeloid cell leukaemia 1 (MCL1) is a pro-survival Bcl-2 family protein that plays important roles in cell survival, proliferation, differentiation and tumourigenesis. MCL1 is a fast-turnover protein that is degraded via an ubiquitination/proteasome-dependent mechanism. Although several E...

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Detalles Bibliográficos
Autores principales: Wu, Lanqin, Lin, Yingying, Feng, Jinan, Qi, Yuanlin, Wang, Xinrui, Lin, Qiaofa, Shi, Wanyan, Zheng, Enrun, Wang, Wei, Hou, Zhenzhu, Lin, Hanbin, Yu, Cheng, He, Yan, Xu, Yan, Yang, Hong, Lin, Ling, Li, Lisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712616/
https://www.ncbi.nlm.nih.gov/pubmed/31467488
http://dx.doi.org/10.1186/s12935-019-0936-5

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