P53-R273H mutation enhances colorectal cancer stemness through regulating specific lncRNAs

BACKGROUND: TP53 is one of the most frequently mutated genes among all cancer types, and TP53 mutants occur more than 60% in colorectal cancer (CRC). Among all mutants, there are three hot spots, including p53-R175H, p53-R248W and p53-R273H. Emerging evidence attributes cancer carcinogenesis to canc...

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Detalles Bibliográficos
Autores principales: Zhao, Yuechao, Li, Yiran, Sheng, Jie, Wu, Fan, Li, Kai, Huang, Rong, Wang, Xiaojuan, Jiao, Tao, Guan, Xin, Lu, Yan, Chen, Xiao, Luo, Zhiwen, Zhou, Yanchi, Hu, Hanjie, Liu, Wenjie, Du, Boyu, Miao, Shiying, Cai, Jianqiang, Wang, Linfang, Zhao, Hong, Ying, Jianming, Bi, Xinyu, Song, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712617/
https://www.ncbi.nlm.nih.gov/pubmed/31455383
http://dx.doi.org/10.1186/s13046-019-1375-9

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