Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K/AKT/mTOR/autophagy pathway in ApoE(−/−) mice

BACKGROUND: The protective effect of metformin (MET) on abdominal aortic aneurysm (AAA) has been reported. However, the related mechanism is still poor understood. In this study, we deeply investigated the role of metformin in AAA pathophysiology. METHODS: Angiotensin II (Ang-II) was used to constru...

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Detalles Bibliográficos
Autores principales: Wang, Zhu, Guo, Jingjing, Han, Xinqiang, Xue, Ming, Wang, Wenming, Mi, Lei, Sheng, Yuguo, Ma, Chao, Wu, Jian, Wu, Xuejun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712653/
https://www.ncbi.nlm.nih.gov/pubmed/31467666
http://dx.doi.org/10.1186/s13578-019-0332-9

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