Dabrafenib and Trametinib prolong coagulation through the inhibition of tissue factor in BRAF(v600e) mutated melanoma cells in vitro

BACKGROUND: Neoplastic cells promote a hypercoagulable state by the expression of cell surface proteins, such as tissue factor. In BRAF(v600) mutated melanoma patients upon BRAF inhibitors, a hypercoagulable state correlates with prognosis, while a down-regulation of the hemostatic parameters is obs...

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Detalles Bibliográficos
Autores principales: Scatena, Cristian, Franceschi, Sara, Franzini, Maria, Sanguinetti, Chiara, Romiti, Nadia, Caponi, Laura, Mandalà, Mario, Mazzanti, Chiara Maria, Naccarato, Antonio Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712666/
https://www.ncbi.nlm.nih.gov/pubmed/31467489
http://dx.doi.org/10.1186/s12935-019-0938-3

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