Metformin targets a YAP1-TEAD4 complex via AMPKα to regulate CCNE1/2 in bladder cancer cells

BACKGROUND: Metformin has been reported to function as the anti-tumor inhibiting the growth of different types of cancers, including bladder cancer. But there are few reports on the roles of Yap1, the key molecule of Hippo pathway, in the metformin induced inhibition of bladder cancer (BLCA). We are...

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Detalles Bibliográficos
Autores principales: Wu, Yanju, Zheng, Qianqian, Li, Yan, Wang, Guang, Gao, Shuting, Zhang, Xiaodong, Yan, Xu, Zhang, Xinwen, Xie, Jisheng, Wang, Yuanyuan, Sun, Xun, Meng, Xin, Yin, Bo, Wang, Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712726/
https://www.ncbi.nlm.nih.gov/pubmed/31455378
http://dx.doi.org/10.1186/s13046-019-1346-1

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