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Association of Opioid Use in the Week Before Death Among Patients With Advanced Lung Cancer Having Sepsis
Opioid use can induce immunosuppression; however, it is unclear whether opioid use increases infections in patients with advanced cancers. This study assessed the association between opioid use in the week before death and mortality among patients with advanced lung cancer having sepsis. Data on opi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712763/ https://www.ncbi.nlm.nih.gov/pubmed/31452400 http://dx.doi.org/10.1177/1073274819871326 |
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author | Choi, Hey-ran Song, In-Ae Oh, Tak Kyu |
author_facet | Choi, Hey-ran Song, In-Ae Oh, Tak Kyu |
author_sort | Choi, Hey-ran |
collection | PubMed |
description | Opioid use can induce immunosuppression; however, it is unclear whether opioid use increases infections in patients with advanced cancers. This study assessed the association between opioid use in the week before death and mortality among patients with advanced lung cancer having sepsis. Data on opioid usage in the week before death, general information, and clinical information of the patients were collected retrospectively. The primary outcome was the association between opioid use in the week before death and mortality after sepsis. The study included 980 patients who died of advanced lung cancer between January 2003 and June 2017 (sepsis related: 413, unrelated to sepsis: 567). The average morphine equivalent daily dose in the final week was higher in the sepsis group (313.5 ± 510.5 mg) than in the nonsepsis group (125.2 ± 246.9 mg, P < .001). A significant association was found between the average morphine equivalent daily dose in the final week and mortality due to sepsis (odds ratio: 1.02, 95% confidence interval: 1.01-1.02, P < .001). This was especially evident when the dose was increased by 10 mg in the final week. Furthermore, older age, male sex, and a lower body mass index were associated with an increased risk of mortality after developing sepsis. Opioid use in the week before death may be associated with mortality for patients with advanced lung cancer having sepsis. |
format | Online Article Text |
id | pubmed-6712763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-67127632019-09-05 Association of Opioid Use in the Week Before Death Among Patients With Advanced Lung Cancer Having Sepsis Choi, Hey-ran Song, In-Ae Oh, Tak Kyu Cancer Control Research Article Opioid use can induce immunosuppression; however, it is unclear whether opioid use increases infections in patients with advanced cancers. This study assessed the association between opioid use in the week before death and mortality among patients with advanced lung cancer having sepsis. Data on opioid usage in the week before death, general information, and clinical information of the patients were collected retrospectively. The primary outcome was the association between opioid use in the week before death and mortality after sepsis. The study included 980 patients who died of advanced lung cancer between January 2003 and June 2017 (sepsis related: 413, unrelated to sepsis: 567). The average morphine equivalent daily dose in the final week was higher in the sepsis group (313.5 ± 510.5 mg) than in the nonsepsis group (125.2 ± 246.9 mg, P < .001). A significant association was found between the average morphine equivalent daily dose in the final week and mortality due to sepsis (odds ratio: 1.02, 95% confidence interval: 1.01-1.02, P < .001). This was especially evident when the dose was increased by 10 mg in the final week. Furthermore, older age, male sex, and a lower body mass index were associated with an increased risk of mortality after developing sepsis. Opioid use in the week before death may be associated with mortality for patients with advanced lung cancer having sepsis. SAGE Publications 2019-08-27 /pmc/articles/PMC6712763/ /pubmed/31452400 http://dx.doi.org/10.1177/1073274819871326 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Research Article Choi, Hey-ran Song, In-Ae Oh, Tak Kyu Association of Opioid Use in the Week Before Death Among Patients With Advanced Lung Cancer Having Sepsis |
title | Association of Opioid Use in the Week Before Death Among Patients With Advanced Lung Cancer Having Sepsis |
title_full | Association of Opioid Use in the Week Before Death Among Patients With Advanced Lung Cancer Having Sepsis |
title_fullStr | Association of Opioid Use in the Week Before Death Among Patients With Advanced Lung Cancer Having Sepsis |
title_full_unstemmed | Association of Opioid Use in the Week Before Death Among Patients With Advanced Lung Cancer Having Sepsis |
title_short | Association of Opioid Use in the Week Before Death Among Patients With Advanced Lung Cancer Having Sepsis |
title_sort | association of opioid use in the week before death among patients with advanced lung cancer having sepsis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712763/ https://www.ncbi.nlm.nih.gov/pubmed/31452400 http://dx.doi.org/10.1177/1073274819871326 |
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