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Association of Opioid Use in the Week Before Death Among Patients With Advanced Lung Cancer Having Sepsis

Opioid use can induce immunosuppression; however, it is unclear whether opioid use increases infections in patients with advanced cancers. This study assessed the association between opioid use in the week before death and mortality among patients with advanced lung cancer having sepsis. Data on opi...

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Autores principales: Choi, Hey-ran, Song, In-Ae, Oh, Tak Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712763/
https://www.ncbi.nlm.nih.gov/pubmed/31452400
http://dx.doi.org/10.1177/1073274819871326
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author Choi, Hey-ran
Song, In-Ae
Oh, Tak Kyu
author_facet Choi, Hey-ran
Song, In-Ae
Oh, Tak Kyu
author_sort Choi, Hey-ran
collection PubMed
description Opioid use can induce immunosuppression; however, it is unclear whether opioid use increases infections in patients with advanced cancers. This study assessed the association between opioid use in the week before death and mortality among patients with advanced lung cancer having sepsis. Data on opioid usage in the week before death, general information, and clinical information of the patients were collected retrospectively. The primary outcome was the association between opioid use in the week before death and mortality after sepsis. The study included 980 patients who died of advanced lung cancer between January 2003 and June 2017 (sepsis related: 413, unrelated to sepsis: 567). The average morphine equivalent daily dose in the final week was higher in the sepsis group (313.5 ± 510.5 mg) than in the nonsepsis group (125.2 ± 246.9 mg, P < .001). A significant association was found between the average morphine equivalent daily dose in the final week and mortality due to sepsis (odds ratio: 1.02, 95% confidence interval: 1.01-1.02, P < .001). This was especially evident when the dose was increased by 10 mg in the final week. Furthermore, older age, male sex, and a lower body mass index were associated with an increased risk of mortality after developing sepsis. Opioid use in the week before death may be associated with mortality for patients with advanced lung cancer having sepsis.
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spelling pubmed-67127632019-09-05 Association of Opioid Use in the Week Before Death Among Patients With Advanced Lung Cancer Having Sepsis Choi, Hey-ran Song, In-Ae Oh, Tak Kyu Cancer Control Research Article Opioid use can induce immunosuppression; however, it is unclear whether opioid use increases infections in patients with advanced cancers. This study assessed the association between opioid use in the week before death and mortality among patients with advanced lung cancer having sepsis. Data on opioid usage in the week before death, general information, and clinical information of the patients were collected retrospectively. The primary outcome was the association between opioid use in the week before death and mortality after sepsis. The study included 980 patients who died of advanced lung cancer between January 2003 and June 2017 (sepsis related: 413, unrelated to sepsis: 567). The average morphine equivalent daily dose in the final week was higher in the sepsis group (313.5 ± 510.5 mg) than in the nonsepsis group (125.2 ± 246.9 mg, P < .001). A significant association was found between the average morphine equivalent daily dose in the final week and mortality due to sepsis (odds ratio: 1.02, 95% confidence interval: 1.01-1.02, P < .001). This was especially evident when the dose was increased by 10 mg in the final week. Furthermore, older age, male sex, and a lower body mass index were associated with an increased risk of mortality after developing sepsis. Opioid use in the week before death may be associated with mortality for patients with advanced lung cancer having sepsis. SAGE Publications 2019-08-27 /pmc/articles/PMC6712763/ /pubmed/31452400 http://dx.doi.org/10.1177/1073274819871326 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Article
Choi, Hey-ran
Song, In-Ae
Oh, Tak Kyu
Association of Opioid Use in the Week Before Death Among Patients With Advanced Lung Cancer Having Sepsis
title Association of Opioid Use in the Week Before Death Among Patients With Advanced Lung Cancer Having Sepsis
title_full Association of Opioid Use in the Week Before Death Among Patients With Advanced Lung Cancer Having Sepsis
title_fullStr Association of Opioid Use in the Week Before Death Among Patients With Advanced Lung Cancer Having Sepsis
title_full_unstemmed Association of Opioid Use in the Week Before Death Among Patients With Advanced Lung Cancer Having Sepsis
title_short Association of Opioid Use in the Week Before Death Among Patients With Advanced Lung Cancer Having Sepsis
title_sort association of opioid use in the week before death among patients with advanced lung cancer having sepsis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712763/
https://www.ncbi.nlm.nih.gov/pubmed/31452400
http://dx.doi.org/10.1177/1073274819871326
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