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Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good
The field of pharmacogenomics (PGx) is gradually shifting from the reactive testing of single genes toward the proactive testing of multiple genes to improve treatment outcomes, reduce adverse events, and decrease the burden of unnecessary costs for healthcare systems. Despite the progress in the fi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712791/ https://www.ncbi.nlm.nih.gov/pubmed/31455423 http://dx.doi.org/10.1186/s40246-019-0229-z |
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author | Krebs, Kristi Milani, Lili |
author_facet | Krebs, Kristi Milani, Lili |
author_sort | Krebs, Kristi |
collection | PubMed |
description | The field of pharmacogenomics (PGx) is gradually shifting from the reactive testing of single genes toward the proactive testing of multiple genes to improve treatment outcomes, reduce adverse events, and decrease the burden of unnecessary costs for healthcare systems. Despite the progress in the field of pharmacogenomics, its implementation into routine care has been slow due to several barriers. However, in recent years, the number of studies on the implementation of PGx has increased, all providing a wealth of knowledge on different solutions for overcoming the obstacles that have been emphasized over the past years. This review focuses on some of the challenges faced by these initiatives, the solutions and different approaches for testing that they suggest, and the evidence that they provide regarding the benefits of preemptive PGx testing. |
format | Online Article Text |
id | pubmed-6712791 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-67127912019-08-29 Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good Krebs, Kristi Milani, Lili Hum Genomics Review The field of pharmacogenomics (PGx) is gradually shifting from the reactive testing of single genes toward the proactive testing of multiple genes to improve treatment outcomes, reduce adverse events, and decrease the burden of unnecessary costs for healthcare systems. Despite the progress in the field of pharmacogenomics, its implementation into routine care has been slow due to several barriers. However, in recent years, the number of studies on the implementation of PGx has increased, all providing a wealth of knowledge on different solutions for overcoming the obstacles that have been emphasized over the past years. This review focuses on some of the challenges faced by these initiatives, the solutions and different approaches for testing that they suggest, and the evidence that they provide regarding the benefits of preemptive PGx testing. BioMed Central 2019-08-27 /pmc/articles/PMC6712791/ /pubmed/31455423 http://dx.doi.org/10.1186/s40246-019-0229-z Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Krebs, Kristi Milani, Lili Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good |
title | Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good |
title_full | Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good |
title_fullStr | Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good |
title_full_unstemmed | Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good |
title_short | Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good |
title_sort | translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712791/ https://www.ncbi.nlm.nih.gov/pubmed/31455423 http://dx.doi.org/10.1186/s40246-019-0229-z |
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