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Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice

Tryptophan metabolic pathway is involved in pathogenic mechanisms of asthma. This study aimed to evaluate tryptophan metabolites and neopterin in a group of asthmatic children. Tryptophan metabolites and neopterin were measured in asthmatic children (121, 71 males, 50 females, mean age 11.6 + 3.2 ye...

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Detalles Bibliográficos
Autores principales: Licari, Amelia, Fuchs, Dietmar, Marseglia, Gianluigi, Ciprandi, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712831/
https://www.ncbi.nlm.nih.gov/pubmed/31455379
http://dx.doi.org/10.1186/s13052-019-0699-6
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author Licari, Amelia
Fuchs, Dietmar
Marseglia, Gianluigi
Ciprandi, Giorgio
author_facet Licari, Amelia
Fuchs, Dietmar
Marseglia, Gianluigi
Ciprandi, Giorgio
author_sort Licari, Amelia
collection PubMed
description Tryptophan metabolic pathway is involved in pathogenic mechanisms of asthma. This study aimed to evaluate tryptophan metabolites and neopterin in a group of asthmatic children. Tryptophan metabolites and neopterin were measured in asthmatic children (121, 71 males, 50 females, mean age 11.6 + 3.2 years) and well-matched healthy controls (63, 32 males, 31 females, mean age 10.7 + 2.6 years). Tryptophan, kynurenine, and neopterin levels were significantly higher in asthmatic children than in healthy controls (p < 0.01; p < 0.01; p = 0.0015 respectively). Tryptophan metabolites and neopterin are increased in asthmatic children; these mediators underline the complex mechanisms involved in the immune response in asthma.
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spelling pubmed-67128312019-08-29 Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice Licari, Amelia Fuchs, Dietmar Marseglia, Gianluigi Ciprandi, Giorgio Ital J Pediatr Letter to the Editor Tryptophan metabolic pathway is involved in pathogenic mechanisms of asthma. This study aimed to evaluate tryptophan metabolites and neopterin in a group of asthmatic children. Tryptophan metabolites and neopterin were measured in asthmatic children (121, 71 males, 50 females, mean age 11.6 + 3.2 years) and well-matched healthy controls (63, 32 males, 31 females, mean age 10.7 + 2.6 years). Tryptophan, kynurenine, and neopterin levels were significantly higher in asthmatic children than in healthy controls (p < 0.01; p < 0.01; p = 0.0015 respectively). Tryptophan metabolites and neopterin are increased in asthmatic children; these mediators underline the complex mechanisms involved in the immune response in asthma. BioMed Central 2019-08-28 /pmc/articles/PMC6712831/ /pubmed/31455379 http://dx.doi.org/10.1186/s13052-019-0699-6 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Licari, Amelia
Fuchs, Dietmar
Marseglia, Gianluigi
Ciprandi, Giorgio
Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice
title Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice
title_full Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice
title_fullStr Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice
title_full_unstemmed Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice
title_short Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice
title_sort tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712831/
https://www.ncbi.nlm.nih.gov/pubmed/31455379
http://dx.doi.org/10.1186/s13052-019-0699-6
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