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The prognostic significance of serum gamma-glutamyltransferase levels and AST/ALT in primary hepatic carcinoma

BACKGROUND: Blood counting and the liver function tests, as the routine examinations, can reflect the immune and nutritional status of the body, our aim is to assess the prognostic significance of serum gamma-glutamyltransferase (GGT) levels and AST/ALT in primary hepatic carcinoma. METHODS: Clinico...

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Autores principales: Zhang, Li-xiang, Lv, Yang, Xu, A-Man, Wang, Huan-zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712845/
https://www.ncbi.nlm.nih.gov/pubmed/31455253
http://dx.doi.org/10.1186/s12885-019-6011-8
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author Zhang, Li-xiang
Lv, Yang
Xu, A-Man
Wang, Huan-zhong
author_facet Zhang, Li-xiang
Lv, Yang
Xu, A-Man
Wang, Huan-zhong
author_sort Zhang, Li-xiang
collection PubMed
description BACKGROUND: Blood counting and the liver function tests, as the routine examinations, can reflect the immune and nutritional status of the body, our aim is to assess the prognostic significance of serum gamma-glutamyltransferase (GGT) levels and AST/ALT in primary hepatic carcinoma. METHODS: Clinico-pathological data of 414 patients with primary hepatic carcinoma in the 1st Affiliated Hospital of Anhui Medical College between January 2007 to January 2014 was analyzed retrospectively in this study. Survival curves were described by Kaplan-Meier method and compared by Log-rank test, univariate and multivariate analysis were used to identify the prognostic factors. RESULTS: GGT was positively correlated with the tumor size(P = 0.000), tumor volume (P = 0.000), tumor volume percent (P = 0.004), TNM stage(P = 0.009), 1-year survival rate (P = 0.000), 3- years survival rate (P = 0.000) and 5-years survival rate(P = 0.000). The serum ALT/AST was significantly correlated with age (P = 0.047), tumor size(P = 0.002), tumor volume (P = 0.010), tumor volume percent (P = 0.005), TNM stage(P = 0.006), liver cirrhosis(P = 0.003), 3- years survival rate (P = 0.032) and 5-years survival rate(P = 0.000). The Kaplan-Meier curves showed that the patients with primary hepatic carcinoma had a longer time in the low GGT group and low AST/ALT group, showing a significant difference (P < 0.05). The univariate and multivariate analyses showed that TNM stage, differentiation grade, tumor volume, GGT and AST/ALT were independent factors for predicting overall survival rate of primary hepatic carcinoma patients. CONCLUSIONS: GGT and AST/ALT were independent factors for predicting overall survival rate of primary hepatic carcinoma patients.
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spelling pubmed-67128452019-08-29 The prognostic significance of serum gamma-glutamyltransferase levels and AST/ALT in primary hepatic carcinoma Zhang, Li-xiang Lv, Yang Xu, A-Man Wang, Huan-zhong BMC Cancer Research Article BACKGROUND: Blood counting and the liver function tests, as the routine examinations, can reflect the immune and nutritional status of the body, our aim is to assess the prognostic significance of serum gamma-glutamyltransferase (GGT) levels and AST/ALT in primary hepatic carcinoma. METHODS: Clinico-pathological data of 414 patients with primary hepatic carcinoma in the 1st Affiliated Hospital of Anhui Medical College between January 2007 to January 2014 was analyzed retrospectively in this study. Survival curves were described by Kaplan-Meier method and compared by Log-rank test, univariate and multivariate analysis were used to identify the prognostic factors. RESULTS: GGT was positively correlated with the tumor size(P = 0.000), tumor volume (P = 0.000), tumor volume percent (P = 0.004), TNM stage(P = 0.009), 1-year survival rate (P = 0.000), 3- years survival rate (P = 0.000) and 5-years survival rate(P = 0.000). The serum ALT/AST was significantly correlated with age (P = 0.047), tumor size(P = 0.002), tumor volume (P = 0.010), tumor volume percent (P = 0.005), TNM stage(P = 0.006), liver cirrhosis(P = 0.003), 3- years survival rate (P = 0.032) and 5-years survival rate(P = 0.000). The Kaplan-Meier curves showed that the patients with primary hepatic carcinoma had a longer time in the low GGT group and low AST/ALT group, showing a significant difference (P < 0.05). The univariate and multivariate analyses showed that TNM stage, differentiation grade, tumor volume, GGT and AST/ALT were independent factors for predicting overall survival rate of primary hepatic carcinoma patients. CONCLUSIONS: GGT and AST/ALT were independent factors for predicting overall survival rate of primary hepatic carcinoma patients. BioMed Central 2019-08-27 /pmc/articles/PMC6712845/ /pubmed/31455253 http://dx.doi.org/10.1186/s12885-019-6011-8 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Zhang, Li-xiang
Lv, Yang
Xu, A-Man
Wang, Huan-zhong
The prognostic significance of serum gamma-glutamyltransferase levels and AST/ALT in primary hepatic carcinoma
title The prognostic significance of serum gamma-glutamyltransferase levels and AST/ALT in primary hepatic carcinoma
title_full The prognostic significance of serum gamma-glutamyltransferase levels and AST/ALT in primary hepatic carcinoma
title_fullStr The prognostic significance of serum gamma-glutamyltransferase levels and AST/ALT in primary hepatic carcinoma
title_full_unstemmed The prognostic significance of serum gamma-glutamyltransferase levels and AST/ALT in primary hepatic carcinoma
title_short The prognostic significance of serum gamma-glutamyltransferase levels and AST/ALT in primary hepatic carcinoma
title_sort prognostic significance of serum gamma-glutamyltransferase levels and ast/alt in primary hepatic carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712845/
https://www.ncbi.nlm.nih.gov/pubmed/31455253
http://dx.doi.org/10.1186/s12885-019-6011-8
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