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Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors
BACKGROUND: We aimed to investigate the expression of proteins related with autotaxin (ATX)–lysophosphatidate (LPA) signaling and the clinical implications in primary and metastatic thyroid tumors. METHODS: We constructed tissue microarrays with 545 primary thyroid tumors [338 papillary thyroid carc...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712878/ https://www.ncbi.nlm.nih.gov/pubmed/31455351 http://dx.doi.org/10.1186/s12967-019-2028-7 |
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author | Shin, Eunah Koo, Ja Seung |
author_facet | Shin, Eunah Koo, Ja Seung |
author_sort | Shin, Eunah |
collection | PubMed |
description | BACKGROUND: We aimed to investigate the expression of proteins related with autotaxin (ATX)–lysophosphatidate (LPA) signaling and the clinical implications in primary and metastatic thyroid tumors. METHODS: We constructed tissue microarrays with 545 primary thyroid tumors [338 papillary thyroid carcinoma (PTC), 111 follicular carcinoma (FC), 69 medullary carcinoma (MC), 23 poorly differentiated carcinoma (PDC), and four anaplastic carcinoma (AC)]. Immunohistochemical stains for proteins related to ATX–LPA signaling (e.g., ATX, LPA1, LPA2, and LPA3) were performed. RESULTS: The expression of ATX was highest in MC, while the LPA1 expression was higher in PDC and AC, and the expression of LPA2 and LPA3 was highest in PTC (p < 0.001). Additionally, the expression of ATX, LPA1, and LPA2 was higher in conventional-type PTC than in follicular-variant PTC (p < 0.05). PTC with BRAF V600E mutation showed higher expression of ATX, LPA1, LPA2, and LPA3 than PTC without BRAF V600E mutation (p < 0.001). In univariate analysis, ATX positivity (p = 0.005) and LPA1 positivity (p = 0.014) were correlated with shorter overall survival in PTC. CONCLUSION: Proteins related to the ATX–LPA axis showed different levels of expression in primary thyroid tumors according to subtype. |
format | Online Article Text |
id | pubmed-6712878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-67128782019-09-04 Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors Shin, Eunah Koo, Ja Seung J Transl Med Research BACKGROUND: We aimed to investigate the expression of proteins related with autotaxin (ATX)–lysophosphatidate (LPA) signaling and the clinical implications in primary and metastatic thyroid tumors. METHODS: We constructed tissue microarrays with 545 primary thyroid tumors [338 papillary thyroid carcinoma (PTC), 111 follicular carcinoma (FC), 69 medullary carcinoma (MC), 23 poorly differentiated carcinoma (PDC), and four anaplastic carcinoma (AC)]. Immunohistochemical stains for proteins related to ATX–LPA signaling (e.g., ATX, LPA1, LPA2, and LPA3) were performed. RESULTS: The expression of ATX was highest in MC, while the LPA1 expression was higher in PDC and AC, and the expression of LPA2 and LPA3 was highest in PTC (p < 0.001). Additionally, the expression of ATX, LPA1, and LPA2 was higher in conventional-type PTC than in follicular-variant PTC (p < 0.05). PTC with BRAF V600E mutation showed higher expression of ATX, LPA1, LPA2, and LPA3 than PTC without BRAF V600E mutation (p < 0.001). In univariate analysis, ATX positivity (p = 0.005) and LPA1 positivity (p = 0.014) were correlated with shorter overall survival in PTC. CONCLUSION: Proteins related to the ATX–LPA axis showed different levels of expression in primary thyroid tumors according to subtype. BioMed Central 2019-08-28 /pmc/articles/PMC6712878/ /pubmed/31455351 http://dx.doi.org/10.1186/s12967-019-2028-7 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Shin, Eunah Koo, Ja Seung Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors |
title | Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors |
title_full | Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors |
title_fullStr | Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors |
title_full_unstemmed | Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors |
title_short | Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors |
title_sort | expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712878/ https://www.ncbi.nlm.nih.gov/pubmed/31455351 http://dx.doi.org/10.1186/s12967-019-2028-7 |
work_keys_str_mv | AT shineunah expressionofproteinsrelatedtoautotaxinlysophosphatidatesignalinginthyroidtumors AT koojaseung expressionofproteinsrelatedtoautotaxinlysophosphatidatesignalinginthyroidtumors |