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Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors

BACKGROUND: We aimed to investigate the expression of proteins related with autotaxin (ATX)–lysophosphatidate (LPA) signaling and the clinical implications in primary and metastatic thyroid tumors. METHODS: We constructed tissue microarrays with 545 primary thyroid tumors [338 papillary thyroid carc...

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Autores principales: Shin, Eunah, Koo, Ja Seung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712878/
https://www.ncbi.nlm.nih.gov/pubmed/31455351
http://dx.doi.org/10.1186/s12967-019-2028-7
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author Shin, Eunah
Koo, Ja Seung
author_facet Shin, Eunah
Koo, Ja Seung
author_sort Shin, Eunah
collection PubMed
description BACKGROUND: We aimed to investigate the expression of proteins related with autotaxin (ATX)–lysophosphatidate (LPA) signaling and the clinical implications in primary and metastatic thyroid tumors. METHODS: We constructed tissue microarrays with 545 primary thyroid tumors [338 papillary thyroid carcinoma (PTC), 111 follicular carcinoma (FC), 69 medullary carcinoma (MC), 23 poorly differentiated carcinoma (PDC), and four anaplastic carcinoma (AC)]. Immunohistochemical stains for proteins related to ATX–LPA signaling (e.g., ATX, LPA1, LPA2, and LPA3) were performed. RESULTS: The expression of ATX was highest in MC, while the LPA1 expression was higher in PDC and AC, and the expression of LPA2 and LPA3 was highest in PTC (p < 0.001). Additionally, the expression of ATX, LPA1, and LPA2 was higher in conventional-type PTC than in follicular-variant PTC (p < 0.05). PTC with BRAF V600E mutation showed higher expression of ATX, LPA1, LPA2, and LPA3 than PTC without BRAF V600E mutation (p < 0.001). In univariate analysis, ATX positivity (p = 0.005) and LPA1 positivity (p = 0.014) were correlated with shorter overall survival in PTC. CONCLUSION: Proteins related to the ATX–LPA axis showed different levels of expression in primary thyroid tumors according to subtype.
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spelling pubmed-67128782019-09-04 Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors Shin, Eunah Koo, Ja Seung J Transl Med Research BACKGROUND: We aimed to investigate the expression of proteins related with autotaxin (ATX)–lysophosphatidate (LPA) signaling and the clinical implications in primary and metastatic thyroid tumors. METHODS: We constructed tissue microarrays with 545 primary thyroid tumors [338 papillary thyroid carcinoma (PTC), 111 follicular carcinoma (FC), 69 medullary carcinoma (MC), 23 poorly differentiated carcinoma (PDC), and four anaplastic carcinoma (AC)]. Immunohistochemical stains for proteins related to ATX–LPA signaling (e.g., ATX, LPA1, LPA2, and LPA3) were performed. RESULTS: The expression of ATX was highest in MC, while the LPA1 expression was higher in PDC and AC, and the expression of LPA2 and LPA3 was highest in PTC (p < 0.001). Additionally, the expression of ATX, LPA1, and LPA2 was higher in conventional-type PTC than in follicular-variant PTC (p < 0.05). PTC with BRAF V600E mutation showed higher expression of ATX, LPA1, LPA2, and LPA3 than PTC without BRAF V600E mutation (p < 0.001). In univariate analysis, ATX positivity (p = 0.005) and LPA1 positivity (p = 0.014) were correlated with shorter overall survival in PTC. CONCLUSION: Proteins related to the ATX–LPA axis showed different levels of expression in primary thyroid tumors according to subtype. BioMed Central 2019-08-28 /pmc/articles/PMC6712878/ /pubmed/31455351 http://dx.doi.org/10.1186/s12967-019-2028-7 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Shin, Eunah
Koo, Ja Seung
Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors
title Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors
title_full Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors
title_fullStr Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors
title_full_unstemmed Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors
title_short Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors
title_sort expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712878/
https://www.ncbi.nlm.nih.gov/pubmed/31455351
http://dx.doi.org/10.1186/s12967-019-2028-7
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