SRSF1 and PTBP1 Are trans-Acting Factors That Suppress the Formation of a CD33 Splicing Isoform Linked to Alzheimer’s Disease Risk

A single nucleotide polymorphism (SNP) in exon 2 of the CD33 gene is associated with reduced susceptibility to late-onset Alzheimer’s disease (AD) and causal for elevated mRNA lacking exon 2. In contrast to full-length CD33, transcripts lacking exon 2 result in CD33 protein unable to suppress activa...

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Detalles Bibliográficos
Autores principales: van Bergeijk, Petra, Seneviratne, Uthpala, Aparicio-Prat, Estel, Stanton, Robert, Hasson, Samuel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712934/
https://www.ncbi.nlm.nih.gov/pubmed/31208978
http://dx.doi.org/10.1128/MCB.00568-18

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