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INTRODUCTION OF THE NEW LYMPHOPARIETAL INDEX FOR GASTRIC CANCER PATIENTS

BACKGROUND: The identification of prognostic factors of gastric cancer (GC) has allowed to predict the evolution of patients. AIM: Assess the reliability of the lymphoparietal index in the prediction of long-term survival in GC treated with curative intent. METHOD: Prospective study of the Universid...

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Autores principales: FIGUEROA-GIRALT, Manuel, CSENDES, Attila, CARRILLO, Katya, DANILLA, Stefan, LANZARINI, Enrique, BRAGHETTO, Italo, MUSLEH, Maher, CORTÉS, Solange
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Colégio Brasileiro de Cirurgia Digestiva 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713052/
https://www.ncbi.nlm.nih.gov/pubmed/31460601
http://dx.doi.org/10.1590/0102-672020190001e1441
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author FIGUEROA-GIRALT, Manuel
CSENDES, Attila
CARRILLO, Katya
DANILLA, Stefan
LANZARINI, Enrique
BRAGHETTO, Italo
MUSLEH, Maher
CORTÉS, Solange
author_facet FIGUEROA-GIRALT, Manuel
CSENDES, Attila
CARRILLO, Katya
DANILLA, Stefan
LANZARINI, Enrique
BRAGHETTO, Italo
MUSLEH, Maher
CORTÉS, Solange
author_sort FIGUEROA-GIRALT, Manuel
collection PubMed
description BACKGROUND: The identification of prognostic factors of gastric cancer (GC) has allowed to predict the evolution of patients. AIM: Assess the reliability of the lymphoparietal index in the prediction of long-term survival in GC treated with curative intent. METHOD: Prospective study of the Universidad de Chile Clinical Hospital, between May 2004 and May 2012. Included all gastric cancer surgeries with curative intent. Exclusion criteria were: gastrectomies due to benign lesions, stage 4 cancers, R1 resections, palliative procedures, complete esophagogastrectomies and emergency surgeries. RESULTS: A total of 284 patients were included; of the sample 65.4% were male,mean age of 64.5 years,75% were advanced cancers, 72.5% required a total gastrectomy, 30 lymph nodes harvest. Surgical morbidity and mortality were 17.2% and 1.7%. 5-year survival was 56.9%. The N+/T index could predict long-term survival in all de subgrups (p<0.0001), although had a reliable prediction in early GC (p=0.005), advanced GC (p<0.0001), signet ring cell GC (p<0.0001), proximal GC (p<0.0001) and distal GC (p<0.0001). The ROC curves N+/T index, LNR and T classification presented areas below the curve of 0.789, 0.786 and 0,790 respectively, without a significant statistical difference (p=0.96). CONCLUSION: The N+/T index is a reliable quotient in the prognostic evaluation of gastric adenocarcinoma patients who have been resected with curative intent.
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spelling pubmed-67130522019-09-05 INTRODUCTION OF THE NEW LYMPHOPARIETAL INDEX FOR GASTRIC CANCER PATIENTS FIGUEROA-GIRALT, Manuel CSENDES, Attila CARRILLO, Katya DANILLA, Stefan LANZARINI, Enrique BRAGHETTO, Italo MUSLEH, Maher CORTÉS, Solange Arq Bras Cir Dig Original Article BACKGROUND: The identification of prognostic factors of gastric cancer (GC) has allowed to predict the evolution of patients. AIM: Assess the reliability of the lymphoparietal index in the prediction of long-term survival in GC treated with curative intent. METHOD: Prospective study of the Universidad de Chile Clinical Hospital, between May 2004 and May 2012. Included all gastric cancer surgeries with curative intent. Exclusion criteria were: gastrectomies due to benign lesions, stage 4 cancers, R1 resections, palliative procedures, complete esophagogastrectomies and emergency surgeries. RESULTS: A total of 284 patients were included; of the sample 65.4% were male,mean age of 64.5 years,75% were advanced cancers, 72.5% required a total gastrectomy, 30 lymph nodes harvest. Surgical morbidity and mortality were 17.2% and 1.7%. 5-year survival was 56.9%. The N+/T index could predict long-term survival in all de subgrups (p<0.0001), although had a reliable prediction in early GC (p=0.005), advanced GC (p<0.0001), signet ring cell GC (p<0.0001), proximal GC (p<0.0001) and distal GC (p<0.0001). The ROC curves N+/T index, LNR and T classification presented areas below the curve of 0.789, 0.786 and 0,790 respectively, without a significant statistical difference (p=0.96). CONCLUSION: The N+/T index is a reliable quotient in the prognostic evaluation of gastric adenocarcinoma patients who have been resected with curative intent. Colégio Brasileiro de Cirurgia Digestiva 2019-08-26 /pmc/articles/PMC6713052/ /pubmed/31460601 http://dx.doi.org/10.1590/0102-672020190001e1441 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Original Article
FIGUEROA-GIRALT, Manuel
CSENDES, Attila
CARRILLO, Katya
DANILLA, Stefan
LANZARINI, Enrique
BRAGHETTO, Italo
MUSLEH, Maher
CORTÉS, Solange
INTRODUCTION OF THE NEW LYMPHOPARIETAL INDEX FOR GASTRIC CANCER PATIENTS
title INTRODUCTION OF THE NEW LYMPHOPARIETAL INDEX FOR GASTRIC CANCER PATIENTS
title_full INTRODUCTION OF THE NEW LYMPHOPARIETAL INDEX FOR GASTRIC CANCER PATIENTS
title_fullStr INTRODUCTION OF THE NEW LYMPHOPARIETAL INDEX FOR GASTRIC CANCER PATIENTS
title_full_unstemmed INTRODUCTION OF THE NEW LYMPHOPARIETAL INDEX FOR GASTRIC CANCER PATIENTS
title_short INTRODUCTION OF THE NEW LYMPHOPARIETAL INDEX FOR GASTRIC CANCER PATIENTS
title_sort introduction of the new lymphoparietal index for gastric cancer patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713052/
https://www.ncbi.nlm.nih.gov/pubmed/31460601
http://dx.doi.org/10.1590/0102-672020190001e1441
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