Intraocular administration of tetramethylpyrazine hydrochloride to rats: a direct delivery pathway for brain targeting?

The purpose of this study was to compare the pharmacokinetic profile of tetramethylpyrazine hydrochloride (TMPH) in rat plasma and tissues following intravenous (iv), intragastric (ig) and intraocular (io) administration. After io, ig and iv administration of a single dose at 10 mg/kg, tissue and pl...

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Detalles Bibliográficos
Autores principales: Mao, Dan, Li, Fang, Ma, Qun, Dai, Manman, Zhang, Huimin, Bai, Luyu, He, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713146/
https://www.ncbi.nlm.nih.gov/pubmed/31401891
http://dx.doi.org/10.1080/10717544.2019.1650849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713146/
https://www.ncbi.nlm.nih.gov/pubmed/31401891
http://dx.doi.org/10.1080/10717544.2019.1650849

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