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A New Look at the Functional Organization of the Golgi Ribbon

A characteristic feature of vertebrate cells is a Golgi ribbon consisting of multiple cisternal stacks connected into a single-copy organelle next to the centrosome. Despite numerous studies, the mechanisms that link the stacks together and the functional significance of ribbon formation remain poor...

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Autores principales: Saraste, Jaakko, Prydz, Kristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713163/
https://www.ncbi.nlm.nih.gov/pubmed/31497600
http://dx.doi.org/10.3389/fcell.2019.00171
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author Saraste, Jaakko
Prydz, Kristian
author_facet Saraste, Jaakko
Prydz, Kristian
author_sort Saraste, Jaakko
collection PubMed
description A characteristic feature of vertebrate cells is a Golgi ribbon consisting of multiple cisternal stacks connected into a single-copy organelle next to the centrosome. Despite numerous studies, the mechanisms that link the stacks together and the functional significance of ribbon formation remain poorly understood. Nevertheless, these questions are of considerable interest, since there is increasing evidence that Golgi fragmentation – the unlinking of the stacks in the ribbon – is intimately connected not only to normal physiological processes, such as cell division and migration, but also to pathological states, including neurodegeneration and cancer. Challenging a commonly held view that ribbon architecture involves the formation of homotypic tubular bridges between the Golgi stacks, we present an alternative model, based on direct interaction between the biosynthetic (pre-Golgi) and endocytic (post-Golgi) membrane networks and their connection with the centrosome. We propose that the central domains of these permanent pre- and post-Golgi networks function together in the biogenesis and maintenance of the more transient Golgi stacks, and thereby establish “linker compartments” that dynamically join the stacks together. This model provides insight into the reversible fragmentation of the Golgi ribbon that takes place in dividing and migrating cells and its regulation along a cell surface – Golgi – centrosome axis. Moreover, it helps to understand transport pathways that either traverse or bypass the Golgi stacks and the positioning of the Golgi apparatus in differentiated neuronal, epithelial, and muscle cells.
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spelling pubmed-67131632019-09-06 A New Look at the Functional Organization of the Golgi Ribbon Saraste, Jaakko Prydz, Kristian Front Cell Dev Biol Cell and Developmental Biology A characteristic feature of vertebrate cells is a Golgi ribbon consisting of multiple cisternal stacks connected into a single-copy organelle next to the centrosome. Despite numerous studies, the mechanisms that link the stacks together and the functional significance of ribbon formation remain poorly understood. Nevertheless, these questions are of considerable interest, since there is increasing evidence that Golgi fragmentation – the unlinking of the stacks in the ribbon – is intimately connected not only to normal physiological processes, such as cell division and migration, but also to pathological states, including neurodegeneration and cancer. Challenging a commonly held view that ribbon architecture involves the formation of homotypic tubular bridges between the Golgi stacks, we present an alternative model, based on direct interaction between the biosynthetic (pre-Golgi) and endocytic (post-Golgi) membrane networks and their connection with the centrosome. We propose that the central domains of these permanent pre- and post-Golgi networks function together in the biogenesis and maintenance of the more transient Golgi stacks, and thereby establish “linker compartments” that dynamically join the stacks together. This model provides insight into the reversible fragmentation of the Golgi ribbon that takes place in dividing and migrating cells and its regulation along a cell surface – Golgi – centrosome axis. Moreover, it helps to understand transport pathways that either traverse or bypass the Golgi stacks and the positioning of the Golgi apparatus in differentiated neuronal, epithelial, and muscle cells. Frontiers Media S.A. 2019-08-21 /pmc/articles/PMC6713163/ /pubmed/31497600 http://dx.doi.org/10.3389/fcell.2019.00171 Text en Copyright © 2019 Saraste and Prydz. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Saraste, Jaakko
Prydz, Kristian
A New Look at the Functional Organization of the Golgi Ribbon
title A New Look at the Functional Organization of the Golgi Ribbon
title_full A New Look at the Functional Organization of the Golgi Ribbon
title_fullStr A New Look at the Functional Organization of the Golgi Ribbon
title_full_unstemmed A New Look at the Functional Organization of the Golgi Ribbon
title_short A New Look at the Functional Organization of the Golgi Ribbon
title_sort new look at the functional organization of the golgi ribbon
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713163/
https://www.ncbi.nlm.nih.gov/pubmed/31497600
http://dx.doi.org/10.3389/fcell.2019.00171
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