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Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as potent ALK-L1196M inhibitors

Anaplastic lymphoma kinase (ALK) has been recognised as a promising molecular target of targeted therapy for NSCLC. We performed SAR study of pyrazolo[3,4-b]pyridines to override crizotinib resistance caused by ALK-L1196M mutation and identified a novel and potent L1196M inhibitor, 10g. 10g displaye...

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Detalles Bibliográficos
Autores principales:	Nam, Yunju, Hwang, Dongkeun, Kim, Namdoo, Seo, Hong-Seog, Selim, Khalid B., Sim, Taebo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713165/ https://www.ncbi.nlm.nih.gov/pubmed/31401883 http://dx.doi.org/10.1080/14756366.2019.1639694

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