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Serum alkaline phosphatase levels correlate with long-term mortality solely in peritoneal dialysis patients with residual renal function
Introduction: Increased serum alkaline phosphatase (ALP) is predictive of a higher mortality in patients with end-stage renal disease. However, it remains unknown whether residual renal function (RRF) influences the outcome-association of serum ALP among peritoneal dialysis (PD) patients. Methods: A...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713195/ https://www.ncbi.nlm.nih.gov/pubmed/31409217 http://dx.doi.org/10.1080/0886022X.2019.1646662 |
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author | Zhan, Xiaojiang Yang, Yuting Chen, Yanbing Wei, Xin Xiao, Jun Zhang, Li Yan, Caixia Qiu, Panlin Liu, Siyi Hu, Qinglan Chen, Qinkai Wang, Yu |
author_facet | Zhan, Xiaojiang Yang, Yuting Chen, Yanbing Wei, Xin Xiao, Jun Zhang, Li Yan, Caixia Qiu, Panlin Liu, Siyi Hu, Qinglan Chen, Qinkai Wang, Yu |
author_sort | Zhan, Xiaojiang |
collection | PubMed |
description | Introduction: Increased serum alkaline phosphatase (ALP) is predictive of a higher mortality in patients with end-stage renal disease. However, it remains unknown whether residual renal function (RRF) influences the outcome-association of serum ALP among peritoneal dialysis (PD) patients. Methods: A total of 650 incident PD patients receiving PD catheter implantation in an institute between 1 November 2005 and 28 February 2017 were retrospectively enrolled. These patients were divided into groups with and without RRF (RRF and non-RRF groups) and those with serum ALP levels in tertiles. The Kaplan–Meier method and multivariate Cox proportional hazard models were used to analyze their outcomes based on RRF and serum ALP levels. Results: These 650 patients had a mean age of 49.4 ± 14.0 years old, their median ALP level was 74 U/L (interquartile range (IQR): 59–98). After 28-month (IQR: 14–41) follow-up, 80 patients in RRF group and 40 patients in non-RRF group died. PD patients with the highest serum ALP tertile had significant lower survival (p = .014), when compared to other patients in the RRF group. However, this relationship was not observed in patients in the non-RRF group. After multivariate adjustment, in the RRF group, patients with the highest ALP tertile had a significantly higher risk of mortality (hazard ratio (HR): 2.26, 95% confidence interval (CI): 1.06–4.82, p = .034). Each 10-U/L increase in ALP level was associated with a 4% (HR: 1.04, 95% CI: 1.00–1.08, p = .045) higher mortality risk. Conclusions: Higher serum ALP level is associated with increased mortality solely in PD patients with RRF. |
format | Online Article Text |
id | pubmed-6713195 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-67131952019-09-05 Serum alkaline phosphatase levels correlate with long-term mortality solely in peritoneal dialysis patients with residual renal function Zhan, Xiaojiang Yang, Yuting Chen, Yanbing Wei, Xin Xiao, Jun Zhang, Li Yan, Caixia Qiu, Panlin Liu, Siyi Hu, Qinglan Chen, Qinkai Wang, Yu Ren Fail Clinical Study Introduction: Increased serum alkaline phosphatase (ALP) is predictive of a higher mortality in patients with end-stage renal disease. However, it remains unknown whether residual renal function (RRF) influences the outcome-association of serum ALP among peritoneal dialysis (PD) patients. Methods: A total of 650 incident PD patients receiving PD catheter implantation in an institute between 1 November 2005 and 28 February 2017 were retrospectively enrolled. These patients were divided into groups with and without RRF (RRF and non-RRF groups) and those with serum ALP levels in tertiles. The Kaplan–Meier method and multivariate Cox proportional hazard models were used to analyze their outcomes based on RRF and serum ALP levels. Results: These 650 patients had a mean age of 49.4 ± 14.0 years old, their median ALP level was 74 U/L (interquartile range (IQR): 59–98). After 28-month (IQR: 14–41) follow-up, 80 patients in RRF group and 40 patients in non-RRF group died. PD patients with the highest serum ALP tertile had significant lower survival (p = .014), when compared to other patients in the RRF group. However, this relationship was not observed in patients in the non-RRF group. After multivariate adjustment, in the RRF group, patients with the highest ALP tertile had a significantly higher risk of mortality (hazard ratio (HR): 2.26, 95% confidence interval (CI): 1.06–4.82, p = .034). Each 10-U/L increase in ALP level was associated with a 4% (HR: 1.04, 95% CI: 1.00–1.08, p = .045) higher mortality risk. Conclusions: Higher serum ALP level is associated with increased mortality solely in PD patients with RRF. Taylor & Francis 2019-08-14 /pmc/articles/PMC6713195/ /pubmed/31409217 http://dx.doi.org/10.1080/0886022X.2019.1646662 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Zhan, Xiaojiang Yang, Yuting Chen, Yanbing Wei, Xin Xiao, Jun Zhang, Li Yan, Caixia Qiu, Panlin Liu, Siyi Hu, Qinglan Chen, Qinkai Wang, Yu Serum alkaline phosphatase levels correlate with long-term mortality solely in peritoneal dialysis patients with residual renal function |
title | Serum alkaline phosphatase levels correlate with long-term mortality solely in peritoneal dialysis patients with residual renal function |
title_full | Serum alkaline phosphatase levels correlate with long-term mortality solely in peritoneal dialysis patients with residual renal function |
title_fullStr | Serum alkaline phosphatase levels correlate with long-term mortality solely in peritoneal dialysis patients with residual renal function |
title_full_unstemmed | Serum alkaline phosphatase levels correlate with long-term mortality solely in peritoneal dialysis patients with residual renal function |
title_short | Serum alkaline phosphatase levels correlate with long-term mortality solely in peritoneal dialysis patients with residual renal function |
title_sort | serum alkaline phosphatase levels correlate with long-term mortality solely in peritoneal dialysis patients with residual renal function |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713195/ https://www.ncbi.nlm.nih.gov/pubmed/31409217 http://dx.doi.org/10.1080/0886022X.2019.1646662 |
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