Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model

The apolipoprotein ε4 allele (APOE4) is the strongest genetic risk factor for Alzheimer’s disease (AD). APOE4 carriers develop systemic metabolic dysfunction decades before showing AD symptoms. Accumulating evidence shows that the metabolic dysfunction accelerates AD development, including exacerbat...

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Detalles Bibliográficos
Autores principales: Hoffman, Jared D., Yanckello, Lucille M., Chlipala, George, Hammond, Tyler C., McCulloch, Scott D., Parikh, Ishita, Sun, Sydney, Morganti, Josh M., Green, Stefan J., Lin, Ai-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713395/
https://www.ncbi.nlm.nih.gov/pubmed/31461505
http://dx.doi.org/10.1371/journal.pone.0221828

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713395/
https://www.ncbi.nlm.nih.gov/pubmed/31461505
http://dx.doi.org/10.1371/journal.pone.0221828

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