Cargando…

Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model

The apolipoprotein ε4 allele (APOE4) is the strongest genetic risk factor for Alzheimer’s disease (AD). APOE4 carriers develop systemic metabolic dysfunction decades before showing AD symptoms. Accumulating evidence shows that the metabolic dysfunction accelerates AD development, including exacerbat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hoffman, Jared D., Yanckello, Lucille M., Chlipala, George, Hammond, Tyler C., McCulloch, Scott D., Parikh, Ishita, Sun, Sydney, Morganti, Josh M., Green, Stefan J., Lin, Ai-Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713395/ https://www.ncbi.nlm.nih.gov/pubmed/31461505 http://dx.doi.org/10.1371/journal.pone.0221828

Ejemplares similares

Inulin supplementation prior to mild traumatic brain injury mitigates gut dysbiosis, and brain vascular and white matter deficits in mice
por: Yanckello, Lucille M., et al.
Publicado: (2022)

Inulin Supplementation Mitigates Gut Dysbiosis and Brain Impairment Induced by Mild Traumatic Brain Injury during Chronic Phase
por: Yanckello, Lucille M., et al.
Publicado: (2022)

Prebiotic inulin enhances gut microbial metabolism and anti-inflammation in apolipoprotein E4 mice with sex-specific implications
por: Chang, Ya-Hsuan, et al.
Publicado: (2023)

Murine Gut Microbiome Association With APOE Alleles
por: Parikh, Ishita J., et al.
Publicado: (2020)

Age Drives Distortion of Brain Metabolic, Vascular and Cognitive Functions, and the Gut Microbiome
por: Hoffman, Jared D., et al.
Publicado: (2017)

Neuroimaging Biomarkers of mTOR Inhibition on Vascular and Metabolic Functions in Aging Brain and Alzheimer’s Disease
por: Lee, Jennifer, et al.
Publicado: (2018)

Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice
por: Ma, David, et al.
Publicado: (2018)

Gut microbiome association with brain imaging markers, APOE genotype, calcium and vegetable intakes, and obesity in healthy aging adults
por: Hammond, Tyler C., et al.
Publicado: (2023)

Human Gray and White Matter Metabolomics to Differentiate APOE and Stage Dependent Changes in Alzheimer’s Disease
por: Hammond, Tyler C., et al.
Publicado: (2021)

Synergistic effects of APOE and sex on the gut microbiome of young EFAD transgenic mice
por: Maldonado Weng, Juan, et al.
Publicado: (2019)

Functional recovery outcomes following acute stroke is associated with abundance of gut microbiota related to inflammation, butyrate and secondary bile acid
por: Hammond, Tyler C., et al.
Publicado: (2022)

Caloric Restriction Alters Postprandial Responses of Essential Brain Metabolites in Young Adult Mice
por: Yanckello, Lucille M., et al.
Publicado: (2019)

The Prebiotic Inulin Aggravates Accelerated Atherosclerosis in Hypercholesterolemic APOE*3-Leiden Mice
por: Hoving, Lisa R., et al.
Publicado: (2018)

Epilepsy: neuroinflammation, neurodegeneration, and APOE genotype
por: Aboud, Orwa, et al.
Publicado: (2013)

APOE genetics influence murine gut microbiome
por: Zajac, Diana J., et al.
Publicado: (2022)

The prebiotic inulin modulates gut microbiota but does not ameliorate atherosclerosis in hypercholesterolemic APOE*3-Leiden.CETP mice
por: Hoving, Lisa R., et al.
Publicado: (2018)

The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation
por: Nelson, Maxine R., et al.
Publicado: (2023)

β-amyloid and tau drive early Alzheimer’s disease decline while glucose hypometabolism drives late decline
por: Hammond, Tyler C., et al.
Publicado: (2020)

Preparation and Characterization of Oxidized Inulin Hydrogel for Controlled Drug Delivery
por: Afinjuomo, Franklin, et al.
Publicado: (2019)

Inulin, the gut microbiome and the deeper breath of asthma patients – Novel pathways in asthma treatment
por: Brehm, Corinna Ulrike, et al.
Publicado: (2019)

Bioregional Alterations in Gut Microbiome Contribute to the Plasma Metabolomic Changes in Pigs Fed with Inulin
por: Wu, Weida, et al.
Publicado: (2020)

Sex Differences in Metabolic Indices and Chronic Neuroinflammation in Response to Prolonged High-Fat Diet in ApoE4 Knock-In Mice
por: Mattar, Jennifer M., et al.
Publicado: (2022)

Effect of Dietary Fiber on the Composition of the Murine Dental Microbiome
por: Sedghi, Lea, et al.
Publicado: (2019)

The application of omics technologies in the functional evaluation of inulin and inulin-containing prebiotics dietary supplementation
por: Tsurumaki, M, et al.
Publicado: (2015)

Reproducible changes in the gut microbiome suggest a shift in microbial and host metabolism during spaceflight
por: Jiang, Peng, et al.
Publicado: (2019)

Design and Characterization of Inulin Conjugate for Improved Intracellular and Targeted Delivery of Pyrazinoic Acid to Monocytes
por: Afinjuomo, Franklin, et al.
Publicado: (2019)

Two Types of Inulin Fructotransferases
por: Haraguchi, Kazutomo
Publicado: (2011)

A Practical Source of Inulin
Publicado: (1913)

Dietary calcium phosphate strongly impacts gut microbiome changes elicited by inulin and galacto-oligosaccharides consumption
por: Fuhren, Jori, et al.
Publicado: (2021)

Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel
por: Han, Kai, et al.
Publicado: (2021)

Proteomic analysis of mitochondria in APOE transgenic mice and in response to an ischemic challenge
por: James, Rachel, et al.
Publicado: (2012)

A Novel Perspective on the ApoM-S1P Axis, Highlighting the Metabolism of ApoM and Its Role in Liver Fibrosis and Neuroinflammation
por: Hajny, Stefan, et al.
Publicado: (2017)

The microbiome: A key regulator of stress and neuroinflammation
por: Rea, Kieran, et al.
Publicado: (2016)

Impact of Microbiome–Brain Communication on Neuroinflammation and Neurodegeneration
por: Stolzer, Iris, et al.
Publicado: (2023)

APOE‐modulated Aβ‐induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective
por: Tai, Leon M., et al.
Publicado: (2015)

Synthesis and Characterization of pH-Sensitive Inulin Conjugate of Isoniazid for Monocyte-Targeted Delivery
por: Afinjuomo, Franklin, et al.
Publicado: (2019)

The effects of dietary supplementation with inulin and inulin‐propionate ester on hepatic steatosis in adults with non‐alcoholic fatty liver disease
por: Chambers, Edward S., et al.
Publicado: (2018)

Isoquercetin and inulin synergistically modulate the gut microbiome to prevent development of the metabolic syndrome in mice fed a high fat diet
por: Tan, Si, et al.
Publicado: (2018)

Dietary supplementation with inulin improves lactation performance and serum lipids by regulating the rumen microbiome and metabolome in dairy cows
por: Wang, Yue, et al.
Publicado: (2021)

Inulin alleviates offspring asthma by altering maternal intestinal microbiome composition to increase short-chain fatty acids
por: Yuan, Guifang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_s04n81mqhgjtqd3jp2cv6ocjdq