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Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in Caenorhabditis elegans

Mutations in pre-synaptic voltage-gated calcium channels can lead to familial hemiplegic migraine type 1 (FHM1). While mammalian studies indicate that the migraine brain is hyperexcitable due to enhanced excitation or reduced inhibition, the molecular and cellular mechanisms underlying this excitato...

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Detalles Bibliográficos
Autores principales:	Huang, Yung-Chi, Pirri, Jennifer K, Rayes, Diego, Gao, Shangbang, Mulcahy, Ben, Grant, Jeff, Saheki, Yasunori, Francis, Michael M, Zhen, Mei, Alkema, Mark J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713474/ https://www.ncbi.nlm.nih.gov/pubmed/31364988 http://dx.doi.org/10.7554/eLife.45905

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