Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering

Hybridoma technology is instrumental for the development of novel antibody therapeutics and diagnostics. Recent preclinical and clinical studies highlight the importance of antibody isotype for therapeutic efficacy. However, since the sequence encoding the constant domains is fixed, tuning antibody...

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Detalles Bibliográficos
Autores principales: van der Schoot, Johan M. S., Fennemann, Felix L., Valente, Michael, Dolen, Yusuf, Hagemans, Iris M., Becker, Anouk M. D., Le Gall, Camille M., van Dalen, Duco, Cevirgel, Alper, van Bruggen, Jaco A. C., Engelfriet, Melanie, Caval, Tomislav, Bentlage, Arthur E. H., Fransen, Marieke F., Nederend, Maaike, Leusen, Jeanette H. W., Heck, Albert J. R., Vidarsson, Gestur, Figdor, Carl G., Verdoes, Martijn, Scheeren, Ferenc A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713500/
https://www.ncbi.nlm.nih.gov/pubmed/31489367
http://dx.doi.org/10.1126/sciadv.aaw1822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713500/
https://www.ncbi.nlm.nih.gov/pubmed/31489367
http://dx.doi.org/10.1126/sciadv.aaw1822

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