Cushing’s syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity

Genetic alterations in the PRKACA gene coding for the catalytic α subunit of the cAMP-dependent protein kinase A (PKA-C) are linked to cortisol-secreting adrenocortical adenomas, resulting in Cushing’s syndrome. Among those, a single mutation (L205R) has been found in up to 67% of patients. Because...

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Detalles Bibliográficos
Autores principales: Walker, Caitlin, Wang, Yingjie, Olivieri, Cristina, Karamafrooz, Adak, Casby, Jordan, Bathon, Kerstin, Calebiro, Davide, Gao, Jiali, Bernlohr, David A., Taylor, Susan S., Veglia, Gianluigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713507/
https://www.ncbi.nlm.nih.gov/pubmed/31489371
http://dx.doi.org/10.1126/sciadv.aaw9298

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