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RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats
Nucleotide repeat expansions in the C9orf72 gene are the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Unconventional translation (RAN translation) of C9orf72 repeats generates dipeptide repeat proteins that can cause neurodegeneration. We performed a ge...
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713615/ https://www.ncbi.nlm.nih.gov/pubmed/31358992 http://dx.doi.org/10.1038/s41593-019-0455-7 |
| _version_ | 1783446894307966976 |
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| author | Yamada, Shizuka B. Gendron, Tania F. Niccoli, Teresa Genuth, Naomi R. Grosely, Rosslyn Shi, Yingxiao Glaria, Idoia Kramer, Nicholas J. Nakayama, Lisa Fang, Shirleen Dinger, Tai J. I. Thoeng, Annora Rocha, Gabriel Barna, Maria Puglisi, Joseph D. Partridge, Linda Ichida, Justin K. Isaacs, Adrian M. Petrucelli, Leonard Gitler, Aaron D. |
| author_facet | Yamada, Shizuka B. Gendron, Tania F. Niccoli, Teresa Genuth, Naomi R. Grosely, Rosslyn Shi, Yingxiao Glaria, Idoia Kramer, Nicholas J. Nakayama, Lisa Fang, Shirleen Dinger, Tai J. I. Thoeng, Annora Rocha, Gabriel Barna, Maria Puglisi, Joseph D. Partridge, Linda Ichida, Justin K. Isaacs, Adrian M. Petrucelli, Leonard Gitler, Aaron D. |
| author_sort | Yamada, Shizuka B. |
| collection | PubMed |
| description | Nucleotide repeat expansions in the C9orf72 gene are the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Unconventional translation (RAN translation) of C9orf72 repeats generates dipeptide repeat proteins that can cause neurodegeneration. We performed a genetic screen for regulators of RAN translation and identified small ribosomal protein subunit 25 (RPS25), presenting a potential therapeutic target for c9ALS/FTD and other neurodegenerative diseases caused by nucleotide repeat expansions. |
| format | Online Article Text |
| id | pubmed-6713615 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-67136152020-01-29 RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats Yamada, Shizuka B. Gendron, Tania F. Niccoli, Teresa Genuth, Naomi R. Grosely, Rosslyn Shi, Yingxiao Glaria, Idoia Kramer, Nicholas J. Nakayama, Lisa Fang, Shirleen Dinger, Tai J. I. Thoeng, Annora Rocha, Gabriel Barna, Maria Puglisi, Joseph D. Partridge, Linda Ichida, Justin K. Isaacs, Adrian M. Petrucelli, Leonard Gitler, Aaron D. Nat Neurosci Article Nucleotide repeat expansions in the C9orf72 gene are the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Unconventional translation (RAN translation) of C9orf72 repeats generates dipeptide repeat proteins that can cause neurodegeneration. We performed a genetic screen for regulators of RAN translation and identified small ribosomal protein subunit 25 (RPS25), presenting a potential therapeutic target for c9ALS/FTD and other neurodegenerative diseases caused by nucleotide repeat expansions. 2019-07-29 2019-09 /pmc/articles/PMC6713615/ /pubmed/31358992 http://dx.doi.org/10.1038/s41593-019-0455-7 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Yamada, Shizuka B. Gendron, Tania F. Niccoli, Teresa Genuth, Naomi R. Grosely, Rosslyn Shi, Yingxiao Glaria, Idoia Kramer, Nicholas J. Nakayama, Lisa Fang, Shirleen Dinger, Tai J. I. Thoeng, Annora Rocha, Gabriel Barna, Maria Puglisi, Joseph D. Partridge, Linda Ichida, Justin K. Isaacs, Adrian M. Petrucelli, Leonard Gitler, Aaron D. RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats |
| title | RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats |
| title_full | RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats |
| title_fullStr | RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats |
| title_full_unstemmed | RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats |
| title_short | RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats |
| title_sort | rps25 is required for efficient ran translation of c9orf72 and other neurodegenerative disease-associated nucleotide repeats |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713615/ https://www.ncbi.nlm.nih.gov/pubmed/31358992 http://dx.doi.org/10.1038/s41593-019-0455-7 |
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