Dorsomorphin induces cancer cell apoptosis and sensitizes cancer cells to HSP90 and proteasome inhibitors by reducing nuclear heat shock factor 1 levels

OBJECTIVE: Heat shock factor 1 (HSF1), a transcriptional regulator of heat shock proteins (HSPs), is an attractive therapeutic target for cancer. However, only a few HSF1 inhibitors have been identified so far. METHODS: The mRNA and protein levels of HSF1, HSPs, cleaved PARP, and phosphorylated HSF1...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Na, Wang, Ting, Li, Zongmeng, Ye, Xiaoli, Deng, Bo, Zhuo, Shu, Yao, Pengle, Yang, Mengmei, Mei, Hong, Chen, Xiaofang, Zhu, Tengfei, Chen, Shiting, Wang, Hui, Wang, Jiming, Le, Yingying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Anti-Cancer Association 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713636/
https://www.ncbi.nlm.nih.gov/pubmed/31516744
http://dx.doi.org/10.20892/j.issn.2095-3941.2018.0235

Ejemplares similares

Ejemplares similares