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Quantification of Liver, Subcutaneous, and Visceral Adipose Tissues by MRI Before and After Bariatric Surgery

BACKGROUND: Morbid obesity is a worldwide epidemic and is increasingly treated by bariatric surgery. Fatty liver is a common finding; almost half of all patients with non-alcoholic steatohepatitis develop steatohepatitis. Bariatric surgery improves steatohepatitis documented by liver biopsy and sing...

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Autores principales: Meyer-Gerspach, Anne Christin, Peterli, Ralph, Moor, Michael, Madörin, Philipp, Schötzau, Andreas, Nabers, Diana, Borgwardt, Stefan, Beglinger, Christoph, Bieri, Oliver, Wölnerhanssen, Bettina K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713693/
https://www.ncbi.nlm.nih.gov/pubmed/31089967
http://dx.doi.org/10.1007/s11695-019-03897-2
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author Meyer-Gerspach, Anne Christin
Peterli, Ralph
Moor, Michael
Madörin, Philipp
Schötzau, Andreas
Nabers, Diana
Borgwardt, Stefan
Beglinger, Christoph
Bieri, Oliver
Wölnerhanssen, Bettina K.
author_facet Meyer-Gerspach, Anne Christin
Peterli, Ralph
Moor, Michael
Madörin, Philipp
Schötzau, Andreas
Nabers, Diana
Borgwardt, Stefan
Beglinger, Christoph
Bieri, Oliver
Wölnerhanssen, Bettina K.
author_sort Meyer-Gerspach, Anne Christin
collection PubMed
description BACKGROUND: Morbid obesity is a worldwide epidemic and is increasingly treated by bariatric surgery. Fatty liver is a common finding; almost half of all patients with non-alcoholic steatohepatitis develop steatohepatitis. Bariatric surgery improves steatohepatitis documented by liver biopsy and single voxel magnetic resonance imaging (MRI) techniques. OBJECTIVE: To investigate changes before and after bariatric surgery using whole organ MRI quantification of liver, visceral, and subcutaneous fat. SETTING: University of Basel Hospital and St. Clara Research Ltd, Basel, Switzerland. METHODS: Sixteen morbidly obese patients were evaluated by abdominal MRI-scanning before and 3, 6, 12, and 24 months after bariatric surgery to measure percentage liver fat (%-LF), total liver volume (TLV) and visceral and subcutaneous adipose tissues (VAT and SAT). Fasting plasma samples were taken for measurement of glucose, insulin, blood lipids, and liver biomarkers. In a control group of 12 healthy lean volunteers, the liver biomarker was also measured. RESULTS: The reproducibility of fat quantification by use of MRI was excellent. LF decreased significantly faster than VAT and SAT (%-LF vs. VAT p < 0.001 and %-LF vs. SAT p < 0.001). At certain time points, %-LF, VAT, and SAT were associated with changes in blood lipids and insulin. CONCLUSIONS: MRI quantification offers excellently reproducible results in measurement of liver fat and visceral and subcutaneous adipose tissues. Liver fat decreased significantly faster than visceral or subcutaneous adipose tissue. Decrease in %-LF and VAT is associated with decrease in total cholesterol, LDL, and plasma insulin. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11695-019-03897-2) contains supplementary material, which is available to authorized users.
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spelling pubmed-67136932019-09-13 Quantification of Liver, Subcutaneous, and Visceral Adipose Tissues by MRI Before and After Bariatric Surgery Meyer-Gerspach, Anne Christin Peterli, Ralph Moor, Michael Madörin, Philipp Schötzau, Andreas Nabers, Diana Borgwardt, Stefan Beglinger, Christoph Bieri, Oliver Wölnerhanssen, Bettina K. Obes Surg Original Contributions BACKGROUND: Morbid obesity is a worldwide epidemic and is increasingly treated by bariatric surgery. Fatty liver is a common finding; almost half of all patients with non-alcoholic steatohepatitis develop steatohepatitis. Bariatric surgery improves steatohepatitis documented by liver biopsy and single voxel magnetic resonance imaging (MRI) techniques. OBJECTIVE: To investigate changes before and after bariatric surgery using whole organ MRI quantification of liver, visceral, and subcutaneous fat. SETTING: University of Basel Hospital and St. Clara Research Ltd, Basel, Switzerland. METHODS: Sixteen morbidly obese patients were evaluated by abdominal MRI-scanning before and 3, 6, 12, and 24 months after bariatric surgery to measure percentage liver fat (%-LF), total liver volume (TLV) and visceral and subcutaneous adipose tissues (VAT and SAT). Fasting plasma samples were taken for measurement of glucose, insulin, blood lipids, and liver biomarkers. In a control group of 12 healthy lean volunteers, the liver biomarker was also measured. RESULTS: The reproducibility of fat quantification by use of MRI was excellent. LF decreased significantly faster than VAT and SAT (%-LF vs. VAT p < 0.001 and %-LF vs. SAT p < 0.001). At certain time points, %-LF, VAT, and SAT were associated with changes in blood lipids and insulin. CONCLUSIONS: MRI quantification offers excellently reproducible results in measurement of liver fat and visceral and subcutaneous adipose tissues. Liver fat decreased significantly faster than visceral or subcutaneous adipose tissue. Decrease in %-LF and VAT is associated with decrease in total cholesterol, LDL, and plasma insulin. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11695-019-03897-2) contains supplementary material, which is available to authorized users. Springer US 2019-05-14 2019 /pmc/articles/PMC6713693/ /pubmed/31089967 http://dx.doi.org/10.1007/s11695-019-03897-2 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Contributions
Meyer-Gerspach, Anne Christin
Peterli, Ralph
Moor, Michael
Madörin, Philipp
Schötzau, Andreas
Nabers, Diana
Borgwardt, Stefan
Beglinger, Christoph
Bieri, Oliver
Wölnerhanssen, Bettina K.
Quantification of Liver, Subcutaneous, and Visceral Adipose Tissues by MRI Before and After Bariatric Surgery
title Quantification of Liver, Subcutaneous, and Visceral Adipose Tissues by MRI Before and After Bariatric Surgery
title_full Quantification of Liver, Subcutaneous, and Visceral Adipose Tissues by MRI Before and After Bariatric Surgery
title_fullStr Quantification of Liver, Subcutaneous, and Visceral Adipose Tissues by MRI Before and After Bariatric Surgery
title_full_unstemmed Quantification of Liver, Subcutaneous, and Visceral Adipose Tissues by MRI Before and After Bariatric Surgery
title_short Quantification of Liver, Subcutaneous, and Visceral Adipose Tissues by MRI Before and After Bariatric Surgery
title_sort quantification of liver, subcutaneous, and visceral adipose tissues by mri before and after bariatric surgery
topic Original Contributions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713693/
https://www.ncbi.nlm.nih.gov/pubmed/31089967
http://dx.doi.org/10.1007/s11695-019-03897-2
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