Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge

Circadian disruption aggravates age-related decline and mortality. However, it remains unclear whether circadian enhancement can retard aging in mammals. We previously reported that the small molecule Nobiletin (NOB) activates ROR (retinoid acid receptor-related orphan receptor) nuclear receptors to...

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Detalles Bibliográficos
Autores principales: Nohara, Kazunari, Mallampalli, Venkata, Nemkov, Travis, Wirianto, Marvin, Yang, Jiah, Ye, Youqiong, Sun, Yuxiang, Han, Leng, Esser, Karyn A., Mileykovskaya, Eugenia, D’Alessandro, Angelo, Green, Carla B., Takahashi, Joseph S., Dowhan, William, Yoo, Seung-Hee, Chen, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713763/
https://www.ncbi.nlm.nih.gov/pubmed/31462679
http://dx.doi.org/10.1038/s41467-019-11926-y

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