Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System

Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 convertase C3bBb in the alternative pathway of the complement system. Here we present two crystal structures of FP and two structures of convertase bound FP. A structural core formed...

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Detalles Bibliográficos
Autores principales: Pedersen, Dennis V., Gadeberg, Trine A. F., Thomas, Caroline, Wang, Yong, Joram, Nicolas, Jensen, Rasmus K., Mazarakis, Sofia M. M., Revel, Margot, El Sissy, Carine, Petersen, Steen V., Lindorff-Larsen, Kresten, Thiel, Steffen, Laursen, Nick S., Fremeaux-Bacchi, Véronique, Andersen, Gregers R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713926/
https://www.ncbi.nlm.nih.gov/pubmed/31507604
http://dx.doi.org/10.3389/fimmu.2019.02007

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