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Incidence of and risk factors for totally implantable vascular access device complications in patients with gastric cancer: A retrospective analysis

Totally implantable vascular access devices (TIVADs) are often used to administer chemotherapy by prolonged intravenous infusion. The objective of the present study was to investigate the incidence of long-term complications and identify risk factors associated with TIVAD placement in patients with...

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Autores principales: Okazaki, Mitsuyoshi, Oyama, Katsunobu, Kinoshita, Jun, Miyashita, Tomoharu, Tajima, Hidehiro, Takamura, Hiroyuki, Ninomiya, Itasu, Fushida, Sachio, Ohta, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713938/
https://www.ncbi.nlm.nih.gov/pubmed/31475061
http://dx.doi.org/10.3892/mco.2019.1897
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author Okazaki, Mitsuyoshi
Oyama, Katsunobu
Kinoshita, Jun
Miyashita, Tomoharu
Tajima, Hidehiro
Takamura, Hiroyuki
Ninomiya, Itasu
Fushida, Sachio
Ohta, Tetsuo
author_facet Okazaki, Mitsuyoshi
Oyama, Katsunobu
Kinoshita, Jun
Miyashita, Tomoharu
Tajima, Hidehiro
Takamura, Hiroyuki
Ninomiya, Itasu
Fushida, Sachio
Ohta, Tetsuo
author_sort Okazaki, Mitsuyoshi
collection PubMed
description Totally implantable vascular access devices (TIVADs) are often used to administer chemotherapy by prolonged intravenous infusion. The objective of the present study was to investigate the incidence of long-term complications and identify risk factors associated with TIVAD placement in patients with gastric cancer. A total of 121 patients with gastric cancer who had undergone 150 TIVAD placement procedures for chemotherapy or supportive care were enrolled in the present retrospective cohort study. A number of risk factors were analyzed, including age, sex, hypertension, diabetes mellitus, history of thrombosis, body mass index, disease stage, and site and purpose of TIVAD. In total, 40 TIVADs (26.7%) developed long-term complications, of which 27 (18.0%) were infections, seven (4.7%) were catheter-related deep vein thrombosis (CR-DVT), and six (4.0%) were obstructions. Chemotherapy was associated with an increased rate of infectious adverse events (odds ratio 2.925; 95% CI, 1.104–7.750; P=0.031) according to the multivariate analysis. CR-DVT occurred more frequently in upper arm ports than in chest wall ports; however, this difference was not statistically significant (7.5 vs. 0.0%; P=0.084) according to the univariable analysis. All CR-DVTs developed in the upper arm sites. Chemotherapy and the upper arm site were associated with long-term complications in patients with TIVAD. However, further studies are needed to confirm the findings of the present study and to determine the reasons for the high incidence of long-term complications in these patients.
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spelling pubmed-67139382019-08-31 Incidence of and risk factors for totally implantable vascular access device complications in patients with gastric cancer: A retrospective analysis Okazaki, Mitsuyoshi Oyama, Katsunobu Kinoshita, Jun Miyashita, Tomoharu Tajima, Hidehiro Takamura, Hiroyuki Ninomiya, Itasu Fushida, Sachio Ohta, Tetsuo Mol Clin Oncol Articles Totally implantable vascular access devices (TIVADs) are often used to administer chemotherapy by prolonged intravenous infusion. The objective of the present study was to investigate the incidence of long-term complications and identify risk factors associated with TIVAD placement in patients with gastric cancer. A total of 121 patients with gastric cancer who had undergone 150 TIVAD placement procedures for chemotherapy or supportive care were enrolled in the present retrospective cohort study. A number of risk factors were analyzed, including age, sex, hypertension, diabetes mellitus, history of thrombosis, body mass index, disease stage, and site and purpose of TIVAD. In total, 40 TIVADs (26.7%) developed long-term complications, of which 27 (18.0%) were infections, seven (4.7%) were catheter-related deep vein thrombosis (CR-DVT), and six (4.0%) were obstructions. Chemotherapy was associated with an increased rate of infectious adverse events (odds ratio 2.925; 95% CI, 1.104–7.750; P=0.031) according to the multivariate analysis. CR-DVT occurred more frequently in upper arm ports than in chest wall ports; however, this difference was not statistically significant (7.5 vs. 0.0%; P=0.084) according to the univariable analysis. All CR-DVTs developed in the upper arm sites. Chemotherapy and the upper arm site were associated with long-term complications in patients with TIVAD. However, further studies are needed to confirm the findings of the present study and to determine the reasons for the high incidence of long-term complications in these patients. D.A. Spandidos 2019-10 2019-07-15 /pmc/articles/PMC6713938/ /pubmed/31475061 http://dx.doi.org/10.3892/mco.2019.1897 Text en Copyright: © Okazaki et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Okazaki, Mitsuyoshi
Oyama, Katsunobu
Kinoshita, Jun
Miyashita, Tomoharu
Tajima, Hidehiro
Takamura, Hiroyuki
Ninomiya, Itasu
Fushida, Sachio
Ohta, Tetsuo
Incidence of and risk factors for totally implantable vascular access device complications in patients with gastric cancer: A retrospective analysis
title Incidence of and risk factors for totally implantable vascular access device complications in patients with gastric cancer: A retrospective analysis
title_full Incidence of and risk factors for totally implantable vascular access device complications in patients with gastric cancer: A retrospective analysis
title_fullStr Incidence of and risk factors for totally implantable vascular access device complications in patients with gastric cancer: A retrospective analysis
title_full_unstemmed Incidence of and risk factors for totally implantable vascular access device complications in patients with gastric cancer: A retrospective analysis
title_short Incidence of and risk factors for totally implantable vascular access device complications in patients with gastric cancer: A retrospective analysis
title_sort incidence of and risk factors for totally implantable vascular access device complications in patients with gastric cancer: a retrospective analysis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713938/
https://www.ncbi.nlm.nih.gov/pubmed/31475061
http://dx.doi.org/10.3892/mco.2019.1897
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