Synthesis of Mono-N-Methyl Aromatic Amines from Nitroso Compounds and Methylboronic Acid

[Image: see text] The selective synthesis of mono-N-methyl aromatic amines was achieved by the reaction of aromatic nitroso compounds with methylboronic acid promoted by triethylphosphite under transition metal-free conditions. The target compounds are constructed efficiently without overmethylation...

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Autores principales: Roscales, Silvia, Csákÿ, Aurelio G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713987/
https://www.ncbi.nlm.nih.gov/pubmed/31497712
http://dx.doi.org/10.1021/acsomega.9b01608
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author Roscales, Silvia
Csákÿ, Aurelio G.
author_facet Roscales, Silvia
Csákÿ, Aurelio G.
author_sort Roscales, Silvia
collection PubMed
description [Image: see text] The selective synthesis of mono-N-methyl aromatic amines was achieved by the reaction of aromatic nitroso compounds with methylboronic acid promoted by triethylphosphite under transition metal-free conditions. The target compounds are constructed efficiently without overmethylation, under environmentally benign reaction conditions that do not require bases or reductants and therefore are of interest in pharmaceutical, agricultural, and chemical industries.
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spelling pubmed-67139872019-09-06 Synthesis of Mono-N-Methyl Aromatic Amines from Nitroso Compounds and Methylboronic Acid Roscales, Silvia Csákÿ, Aurelio G. ACS Omega [Image: see text] The selective synthesis of mono-N-methyl aromatic amines was achieved by the reaction of aromatic nitroso compounds with methylboronic acid promoted by triethylphosphite under transition metal-free conditions. The target compounds are constructed efficiently without overmethylation, under environmentally benign reaction conditions that do not require bases or reductants and therefore are of interest in pharmaceutical, agricultural, and chemical industries. American Chemical Society 2019-08-12 /pmc/articles/PMC6713987/ /pubmed/31497712 http://dx.doi.org/10.1021/acsomega.9b01608 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Roscales, Silvia
Csákÿ, Aurelio G.
Synthesis of Mono-N-Methyl Aromatic Amines from Nitroso Compounds and Methylboronic Acid
title Synthesis of Mono-N-Methyl Aromatic Amines from Nitroso Compounds and Methylboronic Acid
title_full Synthesis of Mono-N-Methyl Aromatic Amines from Nitroso Compounds and Methylboronic Acid
title_fullStr Synthesis of Mono-N-Methyl Aromatic Amines from Nitroso Compounds and Methylboronic Acid
title_full_unstemmed Synthesis of Mono-N-Methyl Aromatic Amines from Nitroso Compounds and Methylboronic Acid
title_short Synthesis of Mono-N-Methyl Aromatic Amines from Nitroso Compounds and Methylboronic Acid
title_sort synthesis of mono-n-methyl aromatic amines from nitroso compounds and methylboronic acid
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713987/
https://www.ncbi.nlm.nih.gov/pubmed/31497712
http://dx.doi.org/10.1021/acsomega.9b01608
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