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Proteasome Inhibition Activates Autophagy-Lysosome Pathway Associated With TFEB Dephosphorylation and Nuclear Translocation
Ubiquitin-proteasome pathway (UPS) and autophagy-lysosome pathway (ALP) are the two major protein degradation pathways, which are critical for proteostasis. Growing evidence indicates that proteasome inhibition-induced ALP activation is an adaptive response. Transcription Factor EB (TFEB) is a maste...
Autores principales: | Li, Chunyan, Wang, Xin, Li, Xuezhi, Qiu, Kaixin, Jiao, Fengjuan, Liu, Yidan, Kong, Qingxia, Liu, Yan, Wu, Yili |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713995/ https://www.ncbi.nlm.nih.gov/pubmed/31508418 http://dx.doi.org/10.3389/fcell.2019.00170 |
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