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The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increases with age

BACKGROUND: Aging is known to induce immunosenescence, resulting in alterations in both the innate and adaptive immune system. Here we evaluated the effects of aging on B cell subsets in peripheral blood of 155 immunologically healthy individuals in four age categories (range 20-95y) via multi-param...

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Detalles Bibliográficos
Autores principales:	Muggen, Alice F., de Jong, Madelon, Wolvers-Tettero, Ingrid L. M., Kallemeijn, Martine J., Teodósio, Cristina, Darzentas, Nikos, Stadhouders, Ralph, IJspeert, Hanna, van der Burg, Mirjam, van IJcken, Wilfred FJ, Verhaar, Jan A. N., Abdulahad, Wayel H., Brouwer, Elisabeth, Boots, Annemieke M. H., Hendriks, Rudi W., van Dongen, Jacques J. M., Langerak, Anton W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714092/ https://www.ncbi.nlm.nih.gov/pubmed/31485252 http://dx.doi.org/10.1186/s12979-019-0163-x

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