Isolation of T cell receptor specifically reactive with autologous tumour cells from tumour-infiltrating lymphocytes and construction of T cell receptor engineered T cells for esophageal squamous cell carcinoma

BACKGROUND: T cell receptor-engineered T cells (TCR-Ts) therapy is a promising cancer treatment strategy. Nowadays, most studies focused on identification of high-avidity T cell receptors (TCRs) directed against neoantigens derived from somatic mutations. However, few neoantigens per patient could i...

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Detalles Bibliográficos
Autores principales: Tan, Qin, Zhang, Chaoting, Yang, Wenjun, Liu, Ying, Heyilimu, Palashati, Feng, Dongdong, Xing, Liying, Ke, Yang, Lu, Zheming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714102/
https://www.ncbi.nlm.nih.gov/pubmed/31462302
http://dx.doi.org/10.1186/s40425-019-0709-7

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