Mannose 6‐phosphonate labelling: A key for processing the therapeutic enzyme in Pompe disease

In the search of a better enzyme therapy in Pompe disease, the conjugation of mannose 6‐phosphonates to the recombinant enzyme appeared as an enhancer of its efficacy. Here, we demonstrated that the increased efficacy of the conjugated enzyme is partly due to a higher intracellular maturation becaus...

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Detalles Bibliográficos
Autores principales: Godefroy, Anastasia, Daurat, Morgane, Da Silva, Afitz, Basile, Ilaria, El Cheikh, Khaled, Caillaud, Catherine, Sacconi, Sabrina, Schoser, Benedikt, Charbonné, Henry‐Vincent, Gary‐Bobo, Magali, Morère, Alain, Garcia, Marcel, Maynadier, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714136/
https://www.ncbi.nlm.nih.gov/pubmed/31293082
http://dx.doi.org/10.1111/jcmm.14516

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