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Herbal formula Yangyinjiedu induces lung cancer cell apoptosis via activation of early growth response 1

Traditional Chinese Medicine (TCM) has been extensively used in clinical practices and proven to be effective against cancer. However, the underlying mechanisms remain to be investigated. In this study, we examined the anticancer activities of Chinese herbal formula Yangyinjiedu (YYJD) and found tha...

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Autores principales: Yang, Wenxiao, Kang, Yani, Zhao, Qiang, Bi, Ling, Jiao, Lijing, Gu, Yunzhao, Lu, Jun, Yao, Jialin, Zhou, Di, Sun, Jielin, Zhao, Xiaodong, Xu, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714142/
https://www.ncbi.nlm.nih.gov/pubmed/31237749
http://dx.doi.org/10.1111/jcmm.14501
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author Yang, Wenxiao
Kang, Yani
Zhao, Qiang
Bi, Ling
Jiao, Lijing
Gu, Yunzhao
Lu, Jun
Yao, Jialin
Zhou, Di
Sun, Jielin
Zhao, Xiaodong
Xu, Ling
author_facet Yang, Wenxiao
Kang, Yani
Zhao, Qiang
Bi, Ling
Jiao, Lijing
Gu, Yunzhao
Lu, Jun
Yao, Jialin
Zhou, Di
Sun, Jielin
Zhao, Xiaodong
Xu, Ling
author_sort Yang, Wenxiao
collection PubMed
description Traditional Chinese Medicine (TCM) has been extensively used in clinical practices and proven to be effective against cancer. However, the underlying mechanisms remain to be investigated. In this study, we examined the anticancer activities of Chinese herbal formula Yangyinjiedu (YYJD) and found that YYJD exhibits cytotoxicity against lung cancer cells. Transcriptome analysis indicated that 2178 genes were differentially expressed (P < 0.05) upon YYJD treatment, with 1464 being (67.2%) up‐regulated. Among these, we found that the tumour suppressor early growth response 1 (EGR1) is the most activated. We demonstrated that EGR1 contributes to YYJD‐induced apoptosis in A549. Through dissecting EGR1‐associated transcriptional network, we identified 275 genes as EGR1 direct targets, some targets are involved in apoptosis. Lastly, we observed that YYJD enhances EGR1 expression and induces cell death in tumour xenografts. Collectively, these findings suggest that YYJD exerts its anticancer activities through EGR1 activation, thus providing the evidence for its potential clinical application for lung cancer patients.
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spelling pubmed-67141422019-09-05 Herbal formula Yangyinjiedu induces lung cancer cell apoptosis via activation of early growth response 1 Yang, Wenxiao Kang, Yani Zhao, Qiang Bi, Ling Jiao, Lijing Gu, Yunzhao Lu, Jun Yao, Jialin Zhou, Di Sun, Jielin Zhao, Xiaodong Xu, Ling J Cell Mol Med Original Articles Traditional Chinese Medicine (TCM) has been extensively used in clinical practices and proven to be effective against cancer. However, the underlying mechanisms remain to be investigated. In this study, we examined the anticancer activities of Chinese herbal formula Yangyinjiedu (YYJD) and found that YYJD exhibits cytotoxicity against lung cancer cells. Transcriptome analysis indicated that 2178 genes were differentially expressed (P < 0.05) upon YYJD treatment, with 1464 being (67.2%) up‐regulated. Among these, we found that the tumour suppressor early growth response 1 (EGR1) is the most activated. We demonstrated that EGR1 contributes to YYJD‐induced apoptosis in A549. Through dissecting EGR1‐associated transcriptional network, we identified 275 genes as EGR1 direct targets, some targets are involved in apoptosis. Lastly, we observed that YYJD enhances EGR1 expression and induces cell death in tumour xenografts. Collectively, these findings suggest that YYJD exerts its anticancer activities through EGR1 activation, thus providing the evidence for its potential clinical application for lung cancer patients. John Wiley and Sons Inc. 2019-06-25 2019-09 /pmc/articles/PMC6714142/ /pubmed/31237749 http://dx.doi.org/10.1111/jcmm.14501 Text en © 2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Yang, Wenxiao
Kang, Yani
Zhao, Qiang
Bi, Ling
Jiao, Lijing
Gu, Yunzhao
Lu, Jun
Yao, Jialin
Zhou, Di
Sun, Jielin
Zhao, Xiaodong
Xu, Ling
Herbal formula Yangyinjiedu induces lung cancer cell apoptosis via activation of early growth response 1
title Herbal formula Yangyinjiedu induces lung cancer cell apoptosis via activation of early growth response 1
title_full Herbal formula Yangyinjiedu induces lung cancer cell apoptosis via activation of early growth response 1
title_fullStr Herbal formula Yangyinjiedu induces lung cancer cell apoptosis via activation of early growth response 1
title_full_unstemmed Herbal formula Yangyinjiedu induces lung cancer cell apoptosis via activation of early growth response 1
title_short Herbal formula Yangyinjiedu induces lung cancer cell apoptosis via activation of early growth response 1
title_sort herbal formula yangyinjiedu induces lung cancer cell apoptosis via activation of early growth response 1
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714142/
https://www.ncbi.nlm.nih.gov/pubmed/31237749
http://dx.doi.org/10.1111/jcmm.14501
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