Cargando…

Eosinophils: An imperative histopathological prognostic indicator for oral squamous cell carcinoma

BACKGROUND: Inflammation in tumor microenvironment assists in both promotion and growth of tumor. Tumor-associated tissue eosinophilia (TATE) is the term used when eosinophils are observed in a tumor tissue with inflammatory infiltrate. Although carcinogenesis with inflammation is one of the importa...

Descripción completa

Detalles Bibliográficos
Autores principales: Deepthi, G, Kulkarni, Pavan G, K Nandan, S R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714271/
https://www.ncbi.nlm.nih.gov/pubmed/31516251
http://dx.doi.org/10.4103/jomfp.JOMFP_111_19
_version_ 1783447029652914176
author Deepthi, G
Kulkarni, Pavan G
K Nandan, S R
author_facet Deepthi, G
Kulkarni, Pavan G
K Nandan, S R
author_sort Deepthi, G
collection PubMed
description BACKGROUND: Inflammation in tumor microenvironment assists in both promotion and growth of tumor. Tumor-associated tissue eosinophilia (TATE) is the term used when eosinophils are observed in a tumor tissue with inflammatory infiltrate. Although carcinogenesis with inflammation is one of the important hallmarks, the exact role of eosinophils remains unclear. Various studies on oral squamous cell carcinoma (OSCC) that focused on eosinophils reported both favorable and unfavorable prognosis in cancer tissue, because of which the exact function of eosinophils still remains uncertain. AIMS AND OBJECTIVES: The present study aims at identifying the role of TATE in OSCC and in malignant transformation of oral epithelial dysplasia (OED). MATERIALS AND METHODS: The study includes 70 samples that divided into two groups, of which 50 histopathologically proven cases of different grades of OSCC and 20 cases of OED (oral leukoplakia). Congo red stain was used to stain the tissue sections. Each slide was viewed under high power in 10 consecutive microscopic fields for counting of eosinophils. RESULTS: Statistical analysis of values obtained was done using ANOVA, unpaired t-test and Mann–Whitney test. The results were statistically significant (P < 0.05) with a mean total eosinophil count of 2.12 in OED and 4.31 in OSCC. CONCLUSION: The present study showed higher eosinophil counts in OSCC when compared to dysplasia which should prompt for a thorough evaluation of tumor front for invasiveness. Therefore, tissue eosinophil count may be used as an adjunct to predict the malignant transformation of dysplastic lesions to OSCC.
format Online
Article
Text
id pubmed-6714271
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-67142712019-09-12 Eosinophils: An imperative histopathological prognostic indicator for oral squamous cell carcinoma Deepthi, G Kulkarni, Pavan G K Nandan, S R J Oral Maxillofac Pathol Original Article BACKGROUND: Inflammation in tumor microenvironment assists in both promotion and growth of tumor. Tumor-associated tissue eosinophilia (TATE) is the term used when eosinophils are observed in a tumor tissue with inflammatory infiltrate. Although carcinogenesis with inflammation is one of the important hallmarks, the exact role of eosinophils remains unclear. Various studies on oral squamous cell carcinoma (OSCC) that focused on eosinophils reported both favorable and unfavorable prognosis in cancer tissue, because of which the exact function of eosinophils still remains uncertain. AIMS AND OBJECTIVES: The present study aims at identifying the role of TATE in OSCC and in malignant transformation of oral epithelial dysplasia (OED). MATERIALS AND METHODS: The study includes 70 samples that divided into two groups, of which 50 histopathologically proven cases of different grades of OSCC and 20 cases of OED (oral leukoplakia). Congo red stain was used to stain the tissue sections. Each slide was viewed under high power in 10 consecutive microscopic fields for counting of eosinophils. RESULTS: Statistical analysis of values obtained was done using ANOVA, unpaired t-test and Mann–Whitney test. The results were statistically significant (P < 0.05) with a mean total eosinophil count of 2.12 in OED and 4.31 in OSCC. CONCLUSION: The present study showed higher eosinophil counts in OSCC when compared to dysplasia which should prompt for a thorough evaluation of tumor front for invasiveness. Therefore, tissue eosinophil count may be used as an adjunct to predict the malignant transformation of dysplastic lesions to OSCC. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6714271/ /pubmed/31516251 http://dx.doi.org/10.4103/jomfp.JOMFP_111_19 Text en Copyright: © 2019 Journal of Oral and Maxillofacial Pathology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Deepthi, G
Kulkarni, Pavan G
K Nandan, S R
Eosinophils: An imperative histopathological prognostic indicator for oral squamous cell carcinoma
title Eosinophils: An imperative histopathological prognostic indicator for oral squamous cell carcinoma
title_full Eosinophils: An imperative histopathological prognostic indicator for oral squamous cell carcinoma
title_fullStr Eosinophils: An imperative histopathological prognostic indicator for oral squamous cell carcinoma
title_full_unstemmed Eosinophils: An imperative histopathological prognostic indicator for oral squamous cell carcinoma
title_short Eosinophils: An imperative histopathological prognostic indicator for oral squamous cell carcinoma
title_sort eosinophils: an imperative histopathological prognostic indicator for oral squamous cell carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714271/
https://www.ncbi.nlm.nih.gov/pubmed/31516251
http://dx.doi.org/10.4103/jomfp.JOMFP_111_19
work_keys_str_mv AT deepthig eosinophilsanimperativehistopathologicalprognosticindicatorfororalsquamouscellcarcinoma
AT kulkarnipavang eosinophilsanimperativehistopathologicalprognosticindicatorfororalsquamouscellcarcinoma
AT knandansr eosinophilsanimperativehistopathologicalprognosticindicatorfororalsquamouscellcarcinoma