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Architectural changes in the regional lymph nodes of oral squamous cell carcinoma
BACKGROUND: The lymph nodes (LNs) in oral squamous cell carcinoma (OSCC) are enlarged as a result of reactive lymphadenopathy, metastasis or both. In response to tumor-associated antigens, diverse cell populations of LNs react in different ways, giving rise to a multitude of morphological patterns (...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714281/ https://www.ncbi.nlm.nih.gov/pubmed/31516249 http://dx.doi.org/10.4103/jomfp.JOMFP_71_18 |
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author | Acharya, Swetha Kumari, Nishitha Srivastava, Pragya Arnold, Dewin Nikhil, Krithi |
author_facet | Acharya, Swetha Kumari, Nishitha Srivastava, Pragya Arnold, Dewin Nikhil, Krithi |
author_sort | Acharya, Swetha |
collection | PubMed |
description | BACKGROUND: The lymph nodes (LNs) in oral squamous cell carcinoma (OSCC) are enlarged as a result of reactive lymphadenopathy, metastasis or both. In response to tumor-associated antigens, diverse cell populations of LNs react in different ways, giving rise to a multitude of morphological patterns (MPs). The prognostic value of MPs has been contested. Hence, the aim of the study was to evaluate morphological alterations in the LNs related to LN metastasis (LNM), tumor size, grade and stage and the prognostic value for OSCC. MATERIALS AND METHODS: LN sections of 40 OSCCs were evaluated. Six MPs were observed: germinal center predominance (GCP), lymphocyte predominance (LP), sinus histiocytosis (SH), vascular transformation of sinuses (VTS), lymphocyte depleted (LD) and granulomatous reaction (GR). The data were subjected to Chi-square test. RESULTS: Four-hundred and eighteen nodes were evaluated, of which 24 were metastatic and 394 nonmetastatic. The predominant MP of LN reactivity was of VTS (116 nodes) followed by GCP (105); LP (90), LD (52), SH (43) and GR (12). A significant association was noted between LN status and the MPs. Risk of LNM with LP was less (13%) when compared with GCP (79%). A statistically significant relation was noted between the predominant MP and metastatic and nonmetastatic cases and with the tumor stage. CONCLUSION: GCP pattern prevails in metastatic and advanced-stage tumors. LP or VTS/SH is prominent in early-stage tumors and nonmetastatic cases. MPs indicate the immune status and aid in foreseeing susceptibility to LNM, thus serving as a surrogate marker. |
format | Online Article Text |
id | pubmed-6714281 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-67142812019-09-12 Architectural changes in the regional lymph nodes of oral squamous cell carcinoma Acharya, Swetha Kumari, Nishitha Srivastava, Pragya Arnold, Dewin Nikhil, Krithi J Oral Maxillofac Pathol Original Article BACKGROUND: The lymph nodes (LNs) in oral squamous cell carcinoma (OSCC) are enlarged as a result of reactive lymphadenopathy, metastasis or both. In response to tumor-associated antigens, diverse cell populations of LNs react in different ways, giving rise to a multitude of morphological patterns (MPs). The prognostic value of MPs has been contested. Hence, the aim of the study was to evaluate morphological alterations in the LNs related to LN metastasis (LNM), tumor size, grade and stage and the prognostic value for OSCC. MATERIALS AND METHODS: LN sections of 40 OSCCs were evaluated. Six MPs were observed: germinal center predominance (GCP), lymphocyte predominance (LP), sinus histiocytosis (SH), vascular transformation of sinuses (VTS), lymphocyte depleted (LD) and granulomatous reaction (GR). The data were subjected to Chi-square test. RESULTS: Four-hundred and eighteen nodes were evaluated, of which 24 were metastatic and 394 nonmetastatic. The predominant MP of LN reactivity was of VTS (116 nodes) followed by GCP (105); LP (90), LD (52), SH (43) and GR (12). A significant association was noted between LN status and the MPs. Risk of LNM with LP was less (13%) when compared with GCP (79%). A statistically significant relation was noted between the predominant MP and metastatic and nonmetastatic cases and with the tumor stage. CONCLUSION: GCP pattern prevails in metastatic and advanced-stage tumors. LP or VTS/SH is prominent in early-stage tumors and nonmetastatic cases. MPs indicate the immune status and aid in foreseeing susceptibility to LNM, thus serving as a surrogate marker. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6714281/ /pubmed/31516249 http://dx.doi.org/10.4103/jomfp.JOMFP_71_18 Text en Copyright: © 2019 Journal of Oral and Maxillofacial Pathology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Acharya, Swetha Kumari, Nishitha Srivastava, Pragya Arnold, Dewin Nikhil, Krithi Architectural changes in the regional lymph nodes of oral squamous cell carcinoma |
title | Architectural changes in the regional lymph nodes of oral squamous cell carcinoma |
title_full | Architectural changes in the regional lymph nodes of oral squamous cell carcinoma |
title_fullStr | Architectural changes in the regional lymph nodes of oral squamous cell carcinoma |
title_full_unstemmed | Architectural changes in the regional lymph nodes of oral squamous cell carcinoma |
title_short | Architectural changes in the regional lymph nodes of oral squamous cell carcinoma |
title_sort | architectural changes in the regional lymph nodes of oral squamous cell carcinoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714281/ https://www.ncbi.nlm.nih.gov/pubmed/31516249 http://dx.doi.org/10.4103/jomfp.JOMFP_71_18 |
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