Receptor tyrosine kinase inhibitor Sunitinib and integrin antagonist peptide HM-3 show similar lipid raft dependent biphasic regulation of tumor angiogenesis and metastasis

BACKGROUND: Anti-angiogenesis remains an attractive strategy for cancer therapy. Some anti-angiogenic reagents have bell-shape dose-response curves with higher than the effective doses yielding lower anti-angiogenic effects. In this study, two different types of anti-angiogenic reagents, a receptor...

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Detalles Bibliográficos
Autores principales: Hu, Jialiang, Wang, Wenjing, Liu, Chen, Li, Mengwei, Nice, Edouard, Xu, Hanmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714448/
https://www.ncbi.nlm.nih.gov/pubmed/31462260
http://dx.doi.org/10.1186/s13046-019-1324-7

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