Hepatic Bioactivation of Skin-Sensitizing Drugs to Immunogenic Reactive Metabolites

[Image: see text] The clinical use of some drugs, such as carbamazepine, phenytoin, and allopurinol, is often associated with adverse cutaneous reactions. The bioactivation of drugs into immunologically reactive metabolites by the liver is postulated to be the first step in initiating a downstream c...

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Detalles Bibliográficos
Autores principales: Chong, Lor Huai, Ng, Celine, Li, Huan, Tian, Edmund Feng, Ananthanarayanan, Abhishek, McMillian, Michael, Toh, Yi-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714514/
https://www.ncbi.nlm.nih.gov/pubmed/31497708
http://dx.doi.org/10.1021/acsomega.9b01551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714514/
https://www.ncbi.nlm.nih.gov/pubmed/31497708
http://dx.doi.org/10.1021/acsomega.9b01551

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