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Hepatic Bioactivation of Skin-Sensitizing Drugs to Immunogenic Reactive Metabolites
[Image: see text] The clinical use of some drugs, such as carbamazepine, phenytoin, and allopurinol, is often associated with adverse cutaneous reactions. The bioactivation of drugs into immunologically reactive metabolites by the liver is postulated to be the first step in initiating a downstream c...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714514/ https://www.ncbi.nlm.nih.gov/pubmed/31497708 http://dx.doi.org/10.1021/acsomega.9b01551 |