Cargando…

Ti-Catalyzed Cross-Cyclomagnesiation of 1,2-Dienes in the Total Z,Z,Z-Stereoselective Synthesis of Natural Acetogenin–Chatenaytrienin-1

[Image: see text] The first total synthesis of natural acetogenin, chatenaytrienin-1, was performed in 10 steps and in 41% overall yield using cross-cyclomagnesiation of (6Z)-heptadeca-1,2,6-triene and trideca-11,12-dien-1-ol tetrahydropyran acetal with EtMgBr in the presence of Mg metal and the Cp(...

Descripción completa

Detalles Bibliográficos
Autores principales:	D’yakonov, Vladimir A., Tuktarova, Regina A., Dzhemilev, Usein M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714518/ https://www.ncbi.nlm.nih.gov/pubmed/31497727 http://dx.doi.org/10.1021/acsomega.9b01951

Ejemplares similares

Natural Acetogenins, Chatenaytrienins-1, -2, -3 and -4, Mitochondrial Potential Uncouplers and Autophagy Inducers—Promising Anticancer Agents
por: Dzhemileva, Lilya U., et al.
Publicado: (2023)

Synthesis and Anticancer Activity of Hybrid Molecules Based on Lithocholic and (5Z,9Z)-Tetradeca-5,9-dienedioic Acids Linked via Mono(di,tri,tetra)ethylene Glycol and α,ω-Diaminoalkane Units
por: D’yakonov, Vladimir A., et al.
Publicado: (2021)

Synthesis of New Cu Complex Based on Natural 5Z,9Z-Eicosadienoic Acid: Effective Topoisomerase I Inhibitor and Cytotoxin against the Cisplatin-Resistant Cell Line
por: Dzhemileva, Lilya U., et al.
Publicado: (2019)

Cobalt(I)-Catalyzed [6π + 2π] Cycloaddition of 1,2-Dienes and 1,3-Diynes to N-Carbocholesteroxyazepine in the Synthesis of Previously Undescribed Heterofunctional 9-Azabicyclo[4.2.1]nonadi(tri)enes
por: Kadikova, Gulnara N., et al.
Publicado: (2021)

Pentacyclic Triterpenoids-Based Ionic Compounds: Synthesis, Study of Structure–Antitumor Activity Relationship, Effects on Mitochondria and Activation of Signaling Pathways of Proliferation, Genome Reparation and Early Apoptosis
por: Dzhemileva, Lilya U., et al.
Publicado: (2023)

Synthesis of Functionally Substituted Bicyclo[4.2.1]nona-2,4-dienes and Bicyclo[4.2.1]nona-2,4,7-trienes by Cobalt(I)-catalyzed [6π + 2π] Cycloaddition of 2-Tropylcyclohexanone
por: Kadikova, Gulnara N., et al.
Publicado: (2020)

Direct Synthesis of Polyaromatic Cyclophanes Containing Bis-Methylene-Interrupted Z-Double Bonds and Study of Their Antitumor Activity In Vitro
por: D’yakonov, Vladimir A., et al.
Publicado: (2021)

Synthesis of New Functionally Substituted 9-Azabicyclo[4.2.1]nona-2,4,7-trienes by Cobalt(I)-Catalyzed [6π + 2π]-Cycloaddition of N-Carbocholesteroxyazepine to Alkynes
por: Kadikova, Gulnara N., et al.
Publicado: (2021)

NbCl(5)-Mg Reagent System in Regio- and Stereoselective Synthesis of (2Z)-Alkenylamines and (3Z)-Alkenylols from Substituted 2-Alkynylamines and 3-Alkynylols
por: Kadikova, Rita N., et al.
Publicado: (2021)

New 1,3-Diynoic Derivatives of Natural Lembehyne B: Stereoselective Synthesis, Anticancer, and Neuritogenic Activity
por: Dzhemileva, Lilya U., et al.
Publicado: (2020)

Natural Trienoic Acids as Anticancer Agents: First Stereoselective Synthesis, Cell Cycle Analysis, Induction of Apoptosis, Cell Signaling and Mitochondrial Targeting Studies
por: D’yakonov, Vladimir A., et al.
Publicado: (2021)

First Example of Catalytic Synthesis of Cyclic S-Containing Di- and Triperoxides
por: Makhmudiyarova, Nataliya, et al.
Publicado: (2020)

(Z,Z)-1,4-Diiodo-1,4-bis(trimethylsilyl)buta-1,3-diene
por: Bats, Jan W., et al.
Publicado: (2008)

Preparation of Macrocyclic Z-Enoates and (E,Z)- or (Z,E)-Dienoates through Catalytic Stereoselective Ring-Closing Metathesis
por: Zhang, Hanmo, et al.
Publicado: (2014)

Synthesis and Evaluation of Anticancer Activities of Novel C-28 Guanidine-Functionalized Triterpene Acid Derivatives
por: Spivak, Anna, et al.
Publicado: (2018)

Diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation
por: Kotha, Sambasivarao, et al.
Publicado: (2019)

Chemoselective Reactions of (E)-1,3-Dienes: Cobalt-Mediated Isomerization to (Z)-1,3-Dienes and Reactions with Ethylene
por: Timsina, Yam N., et al.
Publicado: (2014)

Retraction of “Chemoselective Reactions of (E)-1,3-Dienes: Cobalt-Mediated Isomerization to (Z)-1,3-Dienes and Reactions with Ethylene”
por: Timsina, Yam N., et al.
Publicado: (2018)

Aluminacyclopentanes in the synthesis of 3-substituted phospholanes and α,ω-bisphospholanes
por: D’yakonov, Vladimir A, et al.
Publicado: (2016)

Selective E to Z isomerization of 1,3-Dienes Enabled by A Dinuclear Mechanism
por: Kudo, Eiji, et al.
Publicado: (2021)

Regio- and Stereoselective Switchable Synthesis of (E)- and (Z)-N-Carbonylvinylated Pyrazoles
por: Zhang, Xue, et al.
Publicado: (2023)

Investigation of $H_{SUSY}\to Z Z, Z Z^{*}\to 4 leptons$
por: Kinnunen, Ritva
Publicado: (1997)

On the Z(1)-dependence of electronic stopping in TiN
por: Sortica, Mauricio A., et al.
Publicado: (2019)

Synthesis of C(60) Fullerene–Quadricyclane Hybrid Compound and Its Preliminary In Vitro Antitumor Activity in Combination with Cisplatin
por: Dzhemilev, Usein M., et al.
Publicado: (2019)

Synthesis and anticancer activity novel dimeric azatriperoxides
por: Makhmudiyarova, Nataliya N., et al.
Publicado: (2019)

Z Z and $Z_\gamma$ at LEP2 and interpretations
por: Arcelli, S
Publicado: (2002)

Nickel-catalyzed direct stereoselective α-allylation of ketones with non-conjugated dienes
por: Cao, Yi-Xuan, et al.
Publicado: (2023)

Access to stereodefined (Z)-allylsilanes and (Z)-allylic alcohols via cobalt-catalyzed regioselective hydrosilylation of allenes
por: Wang, Chao, et al.
Publicado: (2017)

Distinct functions of chloroplast FtsZ1 and FtsZ2 in Z-ring structure and remodeling
por: TerBush, Allan D., et al.
Publicado: (2012)

New synthesis of tetraoxaspirododecane-diamines and tetraoxazaspirobicycloalkanes
por: Makhmudiyarova, Nataliya N., et al.
Publicado: (2019)

Z-flipon variants reveal the many roles of Z-DNA and Z-RNA in health and disease
por: Umerenkov, Dmitry, et al.
Publicado: (2023)

TEST: A Z, A&Z, A<Z, A°Z, A Z, A±Z, AµZ End test. Analysis of soft tissue injuries associated with distal radius fractures
por: Ogawa, Takeshi, et al.
Publicado: (2013)

To “Z” or not to “Z”: Z-RNA, self-recognition, and the MDA5 helicase
por: Herbert, Alan
Publicado: (2021)

(Z)-α-Boryl-crotylboron reagents via Z-selective alkene isomerization and application to stereoselective syntheses of (E)-δ-boryl-syn-homoallylic alcohols
por: Gao, Shang, et al.
Publicado: (2019)

Stereoselective synthesis of alkyl-, aryl-, vinyl- and alkynyl-substituted Z-enamides and enol ethers
por: Caramenti, Paola, et al.
Publicado: (2019)

An Anthracene-Thiolate-Ligated Ruthenium Complex: Computational Insights into Z-Stereoselective Cross Metathesis
por: Martínez, Juan Pablo, et al.
Publicado: (2023)

Addendum: Access to stereodefined (Z)-allylsilanes and (Z)-allylic alcohols via cobalt-catalyzed regioselective hydrosilylation of allenes
por: Wang, Chao, et al.
Publicado: (2018)

Color evolution of cluster galaxies from z=0 to z=1
por: Rakos, Karl D., et al.
Publicado: (1994)

The Sarcomeric Z-Disc and Z-Discopathies
por: Knöll, Ralph, et al.
Publicado: (2011)

Search for a Z' at the Z resonance
por: Adriani, O, et al.
Publicado: (1993)

Cannot write session to /tmp/vufind_sessions/sess_6fk1u70k2c29tjv58lr1d6rvs6