Antipsychotic Benzamides Amisulpride and LB-102 Display Polypharmacy as Racemates, S Enantiomers Engage Receptors D(2) and D(3), while R Enantiomers Engage 5-HT(7)

[Image: see text] Benzamide antipsychotics such as amisulpride are dosed as racemates though efficacy is assumed to be mediated through S enantiomer binding to D(2) receptors. At prescribed doses, the benzamides likely display polypharmacy since brain exposure should be sufficient to engage the 5-HT...

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Detalles Bibliográficos
Autores principales: Grattan, Vincent, Vaino, Andrew R., Prensky, Zachary, Hixon, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714530/
https://www.ncbi.nlm.nih.gov/pubmed/31497735
http://dx.doi.org/10.1021/acsomega.9b02144

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