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Thrombin Generation Assay Detects Moderate-Intensity Statin-Induced Reduction of Hypercoagulability in Diabetes

Statins not only have a lipid-lowering effect but also reduce inflammation and have an antithrombotic effect. Since hypercoagulability assessed by thrombin generation assay (TGA) and increased formation of neutrophil extracellular traps (NET) were demonstrated in diabetes, we investigated whether st...

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Autores principales: Park, Hee Sue, Gu, Ja-Yoon, Yoo, Hyun Ju, Han, Se Eun, Park, Chan Ho, Kim, Young Il, Nam-Goong, Il Sung, Kim, Eun Sook, Kim, Hyun Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714759/
https://www.ncbi.nlm.nih.gov/pubmed/29669440
http://dx.doi.org/10.1177/1076029618766254
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author Park, Hee Sue
Gu, Ja-Yoon
Yoo, Hyun Ju
Han, Se Eun
Park, Chan Ho
Kim, Young Il
Nam-Goong, Il Sung
Kim, Eun Sook
Kim, Hyun Kyung
author_facet Park, Hee Sue
Gu, Ja-Yoon
Yoo, Hyun Ju
Han, Se Eun
Park, Chan Ho
Kim, Young Il
Nam-Goong, Il Sung
Kim, Eun Sook
Kim, Hyun Kyung
author_sort Park, Hee Sue
collection PubMed
description Statins not only have a lipid-lowering effect but also reduce inflammation and have an antithrombotic effect. Since hypercoagulability assessed by thrombin generation assay (TGA) and increased formation of neutrophil extracellular traps (NET) were demonstrated in diabetes, we investigated whether statin therapy in diabetes modifies coagulation status and NET formation. Twenty-five consecutive patients with diabetes were recruited. Global coagulation assays (prothrombin time [PT], activated partial thromboplastin time [aPTT], and TGA) and NET markers (DNA–histone complex, cell-free DNA, and neutrophil elastase) were measured before and after 3-month moderate-intensity statin therapy. In addition, all coagulation factors and 3 anticoagulation factors were measured. Statin therapy significantly reduced endogenous thrombin potential (ETP) value and blood lipids but did not change the PT and aPTT values or NET formation markers. Statin significantly decreased not only coagulation factors (II, V, VIII, IX, and X) but also the anticoagulation factor antithrombin. Statin-induced reduction of factor V and X significantly contributed to the reduction of ETP value. The extent of reduction in coagulation factors correlated with that of anticoagulation factors, but not that of cholesterol. It is possible to use TGA as a global coagulation assay that can detect coagulation status modified by statin therapy. Additional studies are needed to evaluate the clinical implications of statin-induced simultaneous reduction of coagulation and anticoagulation factors.
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spelling pubmed-67147592019-09-04 Thrombin Generation Assay Detects Moderate-Intensity Statin-Induced Reduction of Hypercoagulability in Diabetes Park, Hee Sue Gu, Ja-Yoon Yoo, Hyun Ju Han, Se Eun Park, Chan Ho Kim, Young Il Nam-Goong, Il Sung Kim, Eun Sook Kim, Hyun Kyung Clin Appl Thromb Hemost Original Articles Statins not only have a lipid-lowering effect but also reduce inflammation and have an antithrombotic effect. Since hypercoagulability assessed by thrombin generation assay (TGA) and increased formation of neutrophil extracellular traps (NET) were demonstrated in diabetes, we investigated whether statin therapy in diabetes modifies coagulation status and NET formation. Twenty-five consecutive patients with diabetes were recruited. Global coagulation assays (prothrombin time [PT], activated partial thromboplastin time [aPTT], and TGA) and NET markers (DNA–histone complex, cell-free DNA, and neutrophil elastase) were measured before and after 3-month moderate-intensity statin therapy. In addition, all coagulation factors and 3 anticoagulation factors were measured. Statin therapy significantly reduced endogenous thrombin potential (ETP) value and blood lipids but did not change the PT and aPTT values or NET formation markers. Statin significantly decreased not only coagulation factors (II, V, VIII, IX, and X) but also the anticoagulation factor antithrombin. Statin-induced reduction of factor V and X significantly contributed to the reduction of ETP value. The extent of reduction in coagulation factors correlated with that of anticoagulation factors, but not that of cholesterol. It is possible to use TGA as a global coagulation assay that can detect coagulation status modified by statin therapy. Additional studies are needed to evaluate the clinical implications of statin-induced simultaneous reduction of coagulation and anticoagulation factors. SAGE Publications 2018-04-18 2018-10 /pmc/articles/PMC6714759/ /pubmed/29669440 http://dx.doi.org/10.1177/1076029618766254 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Park, Hee Sue
Gu, Ja-Yoon
Yoo, Hyun Ju
Han, Se Eun
Park, Chan Ho
Kim, Young Il
Nam-Goong, Il Sung
Kim, Eun Sook
Kim, Hyun Kyung
Thrombin Generation Assay Detects Moderate-Intensity Statin-Induced Reduction of Hypercoagulability in Diabetes
title Thrombin Generation Assay Detects Moderate-Intensity Statin-Induced Reduction of Hypercoagulability in Diabetes
title_full Thrombin Generation Assay Detects Moderate-Intensity Statin-Induced Reduction of Hypercoagulability in Diabetes
title_fullStr Thrombin Generation Assay Detects Moderate-Intensity Statin-Induced Reduction of Hypercoagulability in Diabetes
title_full_unstemmed Thrombin Generation Assay Detects Moderate-Intensity Statin-Induced Reduction of Hypercoagulability in Diabetes
title_short Thrombin Generation Assay Detects Moderate-Intensity Statin-Induced Reduction of Hypercoagulability in Diabetes
title_sort thrombin generation assay detects moderate-intensity statin-induced reduction of hypercoagulability in diabetes
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714759/
https://www.ncbi.nlm.nih.gov/pubmed/29669440
http://dx.doi.org/10.1177/1076029618766254
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