An Evaluation of Hemostatic Abnormalities in Patients With Hemophilia According to the Activated Partial Thromboplastin Time Waveform

The usefulness of the waveform of activated partial thromboplastin time (APTT) in various diseases has been evaluated in recent years. The APTT waveform was examined in patients with hemophilia and patients positive for lupus anticoagulant (LA). The correlation with the FVIII activity was highest fo...

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Autores principales: Katayama, Haruna, Matsumoto, Takeshi, Wada, Hideo, Fujimoto, Naoki, Toyoda, Junki, Abe, Yasunori, Ohishi, Kohshi, Yamashita, Yoshiki, Ikejiri, Makoto, Habe, Koji, Katayama, Naoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
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Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714760/
https://www.ncbi.nlm.nih.gov/pubmed/29439640
http://dx.doi.org/10.1177/1076029618757344
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author Katayama, Haruna
Matsumoto, Takeshi
Wada, Hideo
Fujimoto, Naoki
Toyoda, Junki
Abe, Yasunori
Ohishi, Kohshi
Yamashita, Yoshiki
Ikejiri, Makoto
Habe, Koji
Katayama, Naoyuki
author_facet Katayama, Haruna
Matsumoto, Takeshi
Wada, Hideo
Fujimoto, Naoki
Toyoda, Junki
Abe, Yasunori
Ohishi, Kohshi
Yamashita, Yoshiki
Ikejiri, Makoto
Habe, Koji
Katayama, Naoyuki
author_sort Katayama, Haruna
collection PubMed
description The usefulness of the waveform of activated partial thromboplastin time (APTT) in various diseases has been evaluated in recent years. The APTT waveform was examined in patients with hemophilia and patients positive for lupus anticoagulant (LA). The correlation with the FVIII activity was highest for the height of acceleration peak. The peak time of acceleration, velocity, and ½ fibrin formation, and the width of acceleration and velocity were significantly long and the height of acceleration was significantly low in patients with hemophilia. The height of velocity was significantly low in patients with hemophilia with inhibitor. There were no significant differences in the APTT waveform between patients with hemophilia and patients with LA, but the peak of acceleration and ½ fibrin formation were significantly longer and the height of acceleration and velocity were significantly lower in patients with hemophilia with inhibitor than in the patients with LA. Wave changes in the APTT were observed in all 22 patients positive for LA, while a biphasic waveform was observed in patients with hemophilia with FVIII activity <10.0%. The APTT waveform is useful for the analysis of hemostatic abnormalities in patients with hemophilia.
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spelling pubmed-67147602019-09-04 An Evaluation of Hemostatic Abnormalities in Patients With Hemophilia According to the Activated Partial Thromboplastin Time Waveform Katayama, Haruna Matsumoto, Takeshi Wada, Hideo Fujimoto, Naoki Toyoda, Junki Abe, Yasunori Ohishi, Kohshi Yamashita, Yoshiki Ikejiri, Makoto Habe, Koji Katayama, Naoyuki Clin Appl Thromb Hemost Original Articles The usefulness of the waveform of activated partial thromboplastin time (APTT) in various diseases has been evaluated in recent years. The APTT waveform was examined in patients with hemophilia and patients positive for lupus anticoagulant (LA). The correlation with the FVIII activity was highest for the height of acceleration peak. The peak time of acceleration, velocity, and ½ fibrin formation, and the width of acceleration and velocity were significantly long and the height of acceleration was significantly low in patients with hemophilia. The height of velocity was significantly low in patients with hemophilia with inhibitor. There were no significant differences in the APTT waveform between patients with hemophilia and patients with LA, but the peak of acceleration and ½ fibrin formation were significantly longer and the height of acceleration and velocity were significantly lower in patients with hemophilia with inhibitor than in the patients with LA. Wave changes in the APTT were observed in all 22 patients positive for LA, while a biphasic waveform was observed in patients with hemophilia with FVIII activity <10.0%. The APTT waveform is useful for the analysis of hemostatic abnormalities in patients with hemophilia. SAGE Publications 2018-02-13 2018-10 /pmc/articles/PMC6714760/ /pubmed/29439640 http://dx.doi.org/10.1177/1076029618757344 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Katayama, Haruna
Matsumoto, Takeshi
Wada, Hideo
Fujimoto, Naoki
Toyoda, Junki
Abe, Yasunori
Ohishi, Kohshi
Yamashita, Yoshiki
Ikejiri, Makoto
Habe, Koji
Katayama, Naoyuki
An Evaluation of Hemostatic Abnormalities in Patients With Hemophilia According to the Activated Partial Thromboplastin Time Waveform
title An Evaluation of Hemostatic Abnormalities in Patients With Hemophilia According to the Activated Partial Thromboplastin Time Waveform
title_full An Evaluation of Hemostatic Abnormalities in Patients With Hemophilia According to the Activated Partial Thromboplastin Time Waveform
title_fullStr An Evaluation of Hemostatic Abnormalities in Patients With Hemophilia According to the Activated Partial Thromboplastin Time Waveform
title_full_unstemmed An Evaluation of Hemostatic Abnormalities in Patients With Hemophilia According to the Activated Partial Thromboplastin Time Waveform
title_short An Evaluation of Hemostatic Abnormalities in Patients With Hemophilia According to the Activated Partial Thromboplastin Time Waveform
title_sort evaluation of hemostatic abnormalities in patients with hemophilia according to the activated partial thromboplastin time waveform
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714760/
https://www.ncbi.nlm.nih.gov/pubmed/29439640
http://dx.doi.org/10.1177/1076029618757344
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