Functional and Proteomic Analysis of Streptococcus pyogenes Virulence Upon Loss of Its Native Cas9 Nuclease

The public health impact of Streptococcus pyogenes (group A Streptococcus, GAS) as a top 10 cause of infection-related mortality in humans contrasts with its benefit to biotechnology as the main natural source of Cas9 nuclease, the key component of the revolutionary CRISPR-Cas9 gene editing platform...

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Detalles Bibliográficos
Autores principales: Gao, Nina J., Al-Bassam, Mahmoud M., Poudel, Saugat, Wozniak, Jacob M., Gonzalez, David J., Olson, Joshua, Zengler, Karsten, Nizet, Victor, Valderrama, J. Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714885/
https://www.ncbi.nlm.nih.gov/pubmed/31507572
http://dx.doi.org/10.3389/fmicb.2019.01967

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