Cargando…

Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation

Atrial fibrillation (AF) is the most common cardiac arrhythmia in the world and has a high risk of thromboembolism. The most effective approach, catheter ablation, requires evaluation by electrocardiography. The aim of our study was to investigate novel clinical markers that predict restoration of s...

Descripción completa

Detalles Bibliográficos
Autores principales: Namino, Fuminori, Yamakuchi, Munekazu, Iriki, Yasuhisa, Okui, Hideki, Ichiki, Hitoshi, Maenosono, Ryuichi, Oketani, Naoya, Masamoto, Izumi, Miyata, Masaaki, Horiuchi, Masahisa, Hashiguchi, Teruto, Ohishi, Mitsuru, Maruyama, Ikuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714917/
https://www.ncbi.nlm.nih.gov/pubmed/31140290
http://dx.doi.org/10.1177/1076029619851570
_version_ 1783447145112666112
author Namino, Fuminori
Yamakuchi, Munekazu
Iriki, Yasuhisa
Okui, Hideki
Ichiki, Hitoshi
Maenosono, Ryuichi
Oketani, Naoya
Masamoto, Izumi
Miyata, Masaaki
Horiuchi, Masahisa
Hashiguchi, Teruto
Ohishi, Mitsuru
Maruyama, Ikuro
author_facet Namino, Fuminori
Yamakuchi, Munekazu
Iriki, Yasuhisa
Okui, Hideki
Ichiki, Hitoshi
Maenosono, Ryuichi
Oketani, Naoya
Masamoto, Izumi
Miyata, Masaaki
Horiuchi, Masahisa
Hashiguchi, Teruto
Ohishi, Mitsuru
Maruyama, Ikuro
author_sort Namino, Fuminori
collection PubMed
description Atrial fibrillation (AF) is the most common cardiac arrhythmia in the world and has a high risk of thromboembolism. The most effective approach, catheter ablation, requires evaluation by electrocardiography. The aim of our study was to investigate novel clinical markers that predict restoration of sinus rhythm (SR) after catheter ablation. Seventy-eight consecutive patients with AF underwent catheter ablation and were separated into 2 groups: restored SR and recurrent AF. The levels of 4 blood proteins (serum or plasma) and 3 mature microRNAs (miRNAs) and their primary miRNAs (pri-miRNAs) in serum were measured before and after ablation, and the associations between each parameter were analyzed statistically. Soluble thrombomodulin (s-TM) and plasminogen activator inhibitor-1 (PAI-1) levels increased above baseline after ablation in both the restored SR (s-TM 11.55 [2.92] vs 13.75 [3.38], P < .001; PAI-1 25.74 [15.25] vs 37.79 [19.56], P < .001) and recurrent AF (s-TM 10.28 [2.78] vs 11.67 [3.37], P < .001; PAI-1 26.16 [15.70] vs 40.74 [22.55], P < .001) groups. Levels of C-reactive protein and asymmetric dimethylarginine were not significantly changed. Pri-miR-126 levels significantly decreased after ablation in the recurrent AF group, but the other miRNAs and pri-miRNAs did not. The measurement of s-TM and pri-miR-126 in blood was a useful tool to reflect the condition of AF patients with catheter ablation.
format Online
Article
Text
id pubmed-6714917
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-67149172019-09-04 Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation Namino, Fuminori Yamakuchi, Munekazu Iriki, Yasuhisa Okui, Hideki Ichiki, Hitoshi Maenosono, Ryuichi Oketani, Naoya Masamoto, Izumi Miyata, Masaaki Horiuchi, Masahisa Hashiguchi, Teruto Ohishi, Mitsuru Maruyama, Ikuro Clin Appl Thromb Hemost Original Article Atrial fibrillation (AF) is the most common cardiac arrhythmia in the world and has a high risk of thromboembolism. The most effective approach, catheter ablation, requires evaluation by electrocardiography. The aim of our study was to investigate novel clinical markers that predict restoration of sinus rhythm (SR) after catheter ablation. Seventy-eight consecutive patients with AF underwent catheter ablation and were separated into 2 groups: restored SR and recurrent AF. The levels of 4 blood proteins (serum or plasma) and 3 mature microRNAs (miRNAs) and their primary miRNAs (pri-miRNAs) in serum were measured before and after ablation, and the associations between each parameter were analyzed statistically. Soluble thrombomodulin (s-TM) and plasminogen activator inhibitor-1 (PAI-1) levels increased above baseline after ablation in both the restored SR (s-TM 11.55 [2.92] vs 13.75 [3.38], P < .001; PAI-1 25.74 [15.25] vs 37.79 [19.56], P < .001) and recurrent AF (s-TM 10.28 [2.78] vs 11.67 [3.37], P < .001; PAI-1 26.16 [15.70] vs 40.74 [22.55], P < .001) groups. Levels of C-reactive protein and asymmetric dimethylarginine were not significantly changed. Pri-miR-126 levels significantly decreased after ablation in the recurrent AF group, but the other miRNAs and pri-miRNAs did not. The measurement of s-TM and pri-miR-126 in blood was a useful tool to reflect the condition of AF patients with catheter ablation. SAGE Publications 2019-05-29 /pmc/articles/PMC6714917/ /pubmed/31140290 http://dx.doi.org/10.1177/1076029619851570 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Namino, Fuminori
Yamakuchi, Munekazu
Iriki, Yasuhisa
Okui, Hideki
Ichiki, Hitoshi
Maenosono, Ryuichi
Oketani, Naoya
Masamoto, Izumi
Miyata, Masaaki
Horiuchi, Masahisa
Hashiguchi, Teruto
Ohishi, Mitsuru
Maruyama, Ikuro
Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation
title Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation
title_full Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation
title_fullStr Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation
title_full_unstemmed Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation
title_short Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation
title_sort dynamics of soluble thrombomodulin and circulating mirnas in patients with atrial fibrillation undergoing radiofrequency catheter ablation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714917/
https://www.ncbi.nlm.nih.gov/pubmed/31140290
http://dx.doi.org/10.1177/1076029619851570
work_keys_str_mv AT naminofuminori dynamicsofsolublethrombomodulinandcirculatingmirnasinpatientswithatrialfibrillationundergoingradiofrequencycatheterablation
AT yamakuchimunekazu dynamicsofsolublethrombomodulinandcirculatingmirnasinpatientswithatrialfibrillationundergoingradiofrequencycatheterablation
AT irikiyasuhisa dynamicsofsolublethrombomodulinandcirculatingmirnasinpatientswithatrialfibrillationundergoingradiofrequencycatheterablation
AT okuihideki dynamicsofsolublethrombomodulinandcirculatingmirnasinpatientswithatrialfibrillationundergoingradiofrequencycatheterablation
AT ichikihitoshi dynamicsofsolublethrombomodulinandcirculatingmirnasinpatientswithatrialfibrillationundergoingradiofrequencycatheterablation
AT maenosonoryuichi dynamicsofsolublethrombomodulinandcirculatingmirnasinpatientswithatrialfibrillationundergoingradiofrequencycatheterablation
AT oketaninaoya dynamicsofsolublethrombomodulinandcirculatingmirnasinpatientswithatrialfibrillationundergoingradiofrequencycatheterablation
AT masamotoizumi dynamicsofsolublethrombomodulinandcirculatingmirnasinpatientswithatrialfibrillationundergoingradiofrequencycatheterablation
AT miyatamasaaki dynamicsofsolublethrombomodulinandcirculatingmirnasinpatientswithatrialfibrillationundergoingradiofrequencycatheterablation
AT horiuchimasahisa dynamicsofsolublethrombomodulinandcirculatingmirnasinpatientswithatrialfibrillationundergoingradiofrequencycatheterablation
AT hashiguchiteruto dynamicsofsolublethrombomodulinandcirculatingmirnasinpatientswithatrialfibrillationundergoingradiofrequencycatheterablation
AT ohishimitsuru dynamicsofsolublethrombomodulinandcirculatingmirnasinpatientswithatrialfibrillationundergoingradiofrequencycatheterablation
AT maruyamaikuro dynamicsofsolublethrombomodulinandcirculatingmirnasinpatientswithatrialfibrillationundergoingradiofrequencycatheterablation