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Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation
Atrial fibrillation (AF) is the most common cardiac arrhythmia in the world and has a high risk of thromboembolism. The most effective approach, catheter ablation, requires evaluation by electrocardiography. The aim of our study was to investigate novel clinical markers that predict restoration of s...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714917/ https://www.ncbi.nlm.nih.gov/pubmed/31140290 http://dx.doi.org/10.1177/1076029619851570 |
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author | Namino, Fuminori Yamakuchi, Munekazu Iriki, Yasuhisa Okui, Hideki Ichiki, Hitoshi Maenosono, Ryuichi Oketani, Naoya Masamoto, Izumi Miyata, Masaaki Horiuchi, Masahisa Hashiguchi, Teruto Ohishi, Mitsuru Maruyama, Ikuro |
author_facet | Namino, Fuminori Yamakuchi, Munekazu Iriki, Yasuhisa Okui, Hideki Ichiki, Hitoshi Maenosono, Ryuichi Oketani, Naoya Masamoto, Izumi Miyata, Masaaki Horiuchi, Masahisa Hashiguchi, Teruto Ohishi, Mitsuru Maruyama, Ikuro |
author_sort | Namino, Fuminori |
collection | PubMed |
description | Atrial fibrillation (AF) is the most common cardiac arrhythmia in the world and has a high risk of thromboembolism. The most effective approach, catheter ablation, requires evaluation by electrocardiography. The aim of our study was to investigate novel clinical markers that predict restoration of sinus rhythm (SR) after catheter ablation. Seventy-eight consecutive patients with AF underwent catheter ablation and were separated into 2 groups: restored SR and recurrent AF. The levels of 4 blood proteins (serum or plasma) and 3 mature microRNAs (miRNAs) and their primary miRNAs (pri-miRNAs) in serum were measured before and after ablation, and the associations between each parameter were analyzed statistically. Soluble thrombomodulin (s-TM) and plasminogen activator inhibitor-1 (PAI-1) levels increased above baseline after ablation in both the restored SR (s-TM 11.55 [2.92] vs 13.75 [3.38], P < .001; PAI-1 25.74 [15.25] vs 37.79 [19.56], P < .001) and recurrent AF (s-TM 10.28 [2.78] vs 11.67 [3.37], P < .001; PAI-1 26.16 [15.70] vs 40.74 [22.55], P < .001) groups. Levels of C-reactive protein and asymmetric dimethylarginine were not significantly changed. Pri-miR-126 levels significantly decreased after ablation in the recurrent AF group, but the other miRNAs and pri-miRNAs did not. The measurement of s-TM and pri-miR-126 in blood was a useful tool to reflect the condition of AF patients with catheter ablation. |
format | Online Article Text |
id | pubmed-6714917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-67149172019-09-04 Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation Namino, Fuminori Yamakuchi, Munekazu Iriki, Yasuhisa Okui, Hideki Ichiki, Hitoshi Maenosono, Ryuichi Oketani, Naoya Masamoto, Izumi Miyata, Masaaki Horiuchi, Masahisa Hashiguchi, Teruto Ohishi, Mitsuru Maruyama, Ikuro Clin Appl Thromb Hemost Original Article Atrial fibrillation (AF) is the most common cardiac arrhythmia in the world and has a high risk of thromboembolism. The most effective approach, catheter ablation, requires evaluation by electrocardiography. The aim of our study was to investigate novel clinical markers that predict restoration of sinus rhythm (SR) after catheter ablation. Seventy-eight consecutive patients with AF underwent catheter ablation and were separated into 2 groups: restored SR and recurrent AF. The levels of 4 blood proteins (serum or plasma) and 3 mature microRNAs (miRNAs) and their primary miRNAs (pri-miRNAs) in serum were measured before and after ablation, and the associations between each parameter were analyzed statistically. Soluble thrombomodulin (s-TM) and plasminogen activator inhibitor-1 (PAI-1) levels increased above baseline after ablation in both the restored SR (s-TM 11.55 [2.92] vs 13.75 [3.38], P < .001; PAI-1 25.74 [15.25] vs 37.79 [19.56], P < .001) and recurrent AF (s-TM 10.28 [2.78] vs 11.67 [3.37], P < .001; PAI-1 26.16 [15.70] vs 40.74 [22.55], P < .001) groups. Levels of C-reactive protein and asymmetric dimethylarginine were not significantly changed. Pri-miR-126 levels significantly decreased after ablation in the recurrent AF group, but the other miRNAs and pri-miRNAs did not. The measurement of s-TM and pri-miR-126 in blood was a useful tool to reflect the condition of AF patients with catheter ablation. SAGE Publications 2019-05-29 /pmc/articles/PMC6714917/ /pubmed/31140290 http://dx.doi.org/10.1177/1076029619851570 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Article Namino, Fuminori Yamakuchi, Munekazu Iriki, Yasuhisa Okui, Hideki Ichiki, Hitoshi Maenosono, Ryuichi Oketani, Naoya Masamoto, Izumi Miyata, Masaaki Horiuchi, Masahisa Hashiguchi, Teruto Ohishi, Mitsuru Maruyama, Ikuro Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation |
title | Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation |
title_full | Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation |
title_fullStr | Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation |
title_full_unstemmed | Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation |
title_short | Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation |
title_sort | dynamics of soluble thrombomodulin and circulating mirnas in patients with atrial fibrillation undergoing radiofrequency catheter ablation |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714917/ https://www.ncbi.nlm.nih.gov/pubmed/31140290 http://dx.doi.org/10.1177/1076029619851570 |
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