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Association between serum uric acid and nonalcoholic fatty liver disease in community patients with type 2 diabetes mellitus

BACKGROUND: To investigate whether SUA is associated with NAFLD in men and women with T2DM. METHODS: This cross-sectional study enrolled patients with T2DM at Shanxi High-Tech Development Zone Central Hospital (June 2011 to September 2017). Patients were stratified according to gender and presence/a...

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Autores principales: Xu, Linxin, Li, Ting, Yin, Jianhong, Lin, Gang, Xu, Yali, Ren, Yi, Wang, Yan, Yang, Jing, Chen, Liming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714965/
https://www.ncbi.nlm.nih.gov/pubmed/31523513
http://dx.doi.org/10.7717/peerj.7563
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author Xu, Linxin
Li, Ting
Yin, Jianhong
Lin, Gang
Xu, Yali
Ren, Yi
Wang, Yan
Yang, Jing
Chen, Liming
author_facet Xu, Linxin
Li, Ting
Yin, Jianhong
Lin, Gang
Xu, Yali
Ren, Yi
Wang, Yan
Yang, Jing
Chen, Liming
author_sort Xu, Linxin
collection PubMed
description BACKGROUND: To investigate whether SUA is associated with NAFLD in men and women with T2DM. METHODS: This cross-sectional study enrolled patients with T2DM at Shanxi High-Tech Development Zone Central Hospital (June 2011 to September 2017). Patients were stratified according to gender and presence/absence of NAFLD. Parameters associated with NAFLD were identified using multivariate stepwise linear regression and univariate/multivariate logistic regression. RESULTS: Among 597 patients (325 males) enrolled, 352 had NAFLD. SUA was higher in the NAFLD group than in the non-NAFLD group for both men and women (P < 0.001). Multiple linear regression showed that body mass index (positively), triglycerides (positively) and estimated glomerular filtration rate (negatively) were independently related to SUA (P < 0.001). Univariate logistic regression revealed increased odds of NAFLD for SUA tertiles 2 (P = 0.022) and 3 (P = 0.001) in women and tertile 3 (P = 0.039) in men. After adjustment for multiple clinical parameters, SUA tertiles were significantly associated with NAFLD for tertile 3 in women (P = 0.014), although there were trends toward associations for tertile 2 in women (P = 0.074) and tertiles 2 and 3 in men (P = 0.085 and 0.054, respectively). CONCLUSION: SUA is not independently associated with NAFLD in men or women with T2DM after rigorous adjustment for other metabolic parameters.
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spelling pubmed-67149652019-09-13 Association between serum uric acid and nonalcoholic fatty liver disease in community patients with type 2 diabetes mellitus Xu, Linxin Li, Ting Yin, Jianhong Lin, Gang Xu, Yali Ren, Yi Wang, Yan Yang, Jing Chen, Liming PeerJ Bioinformatics BACKGROUND: To investigate whether SUA is associated with NAFLD in men and women with T2DM. METHODS: This cross-sectional study enrolled patients with T2DM at Shanxi High-Tech Development Zone Central Hospital (June 2011 to September 2017). Patients were stratified according to gender and presence/absence of NAFLD. Parameters associated with NAFLD were identified using multivariate stepwise linear regression and univariate/multivariate logistic regression. RESULTS: Among 597 patients (325 males) enrolled, 352 had NAFLD. SUA was higher in the NAFLD group than in the non-NAFLD group for both men and women (P < 0.001). Multiple linear regression showed that body mass index (positively), triglycerides (positively) and estimated glomerular filtration rate (negatively) were independently related to SUA (P < 0.001). Univariate logistic regression revealed increased odds of NAFLD for SUA tertiles 2 (P = 0.022) and 3 (P = 0.001) in women and tertile 3 (P = 0.039) in men. After adjustment for multiple clinical parameters, SUA tertiles were significantly associated with NAFLD for tertile 3 in women (P = 0.014), although there were trends toward associations for tertile 2 in women (P = 0.074) and tertiles 2 and 3 in men (P = 0.085 and 0.054, respectively). CONCLUSION: SUA is not independently associated with NAFLD in men or women with T2DM after rigorous adjustment for other metabolic parameters. PeerJ Inc. 2019-08-26 /pmc/articles/PMC6714965/ /pubmed/31523513 http://dx.doi.org/10.7717/peerj.7563 Text en ©2019 Xu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Bioinformatics
Xu, Linxin
Li, Ting
Yin, Jianhong
Lin, Gang
Xu, Yali
Ren, Yi
Wang, Yan
Yang, Jing
Chen, Liming
Association between serum uric acid and nonalcoholic fatty liver disease in community patients with type 2 diabetes mellitus
title Association between serum uric acid and nonalcoholic fatty liver disease in community patients with type 2 diabetes mellitus
title_full Association between serum uric acid and nonalcoholic fatty liver disease in community patients with type 2 diabetes mellitus
title_fullStr Association between serum uric acid and nonalcoholic fatty liver disease in community patients with type 2 diabetes mellitus
title_full_unstemmed Association between serum uric acid and nonalcoholic fatty liver disease in community patients with type 2 diabetes mellitus
title_short Association between serum uric acid and nonalcoholic fatty liver disease in community patients with type 2 diabetes mellitus
title_sort association between serum uric acid and nonalcoholic fatty liver disease in community patients with type 2 diabetes mellitus
topic Bioinformatics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714965/
https://www.ncbi.nlm.nih.gov/pubmed/31523513
http://dx.doi.org/10.7717/peerj.7563
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