Cargando…

Effects of the selective TrkA agonist gambogic amide on pigmentation and growth of human hair follicles in vitro

The human hair follicle is a neuroendocrine mini-organ that can be used to study aging processes in vitro. Neurotrophins maintain homeostasis in hair biology via the Trk-family of receptors. TrkA, the high affinity receptor for nerve growth factor (NGF), is expressed in hair follicle melanocytes and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Campiche, Remo, Daniltchenko, Maria, Imfeld, Dominik, Peters, Eva M. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715186/ https://www.ncbi.nlm.nih.gov/pubmed/31465471 http://dx.doi.org/10.1371/journal.pone.0221757

Ejemplares similares

The selective TrkA agonist, gambogic amide, promotes osteoblastic differentiation and improves fracture healing in mice
por: Johnstone, Maddison R., et al.
Publicado: (2019)

Gambogic amide inhibits angiogenesis by suppressing VEGF/VEGFR2 in endothelial cells in a TrkA-independent manner
por: Sui, Tongtong, et al.
Publicado: (2021)

Discovery of a Highly Selective MC1R Agonists Pentapeptide to Be Used as a Skin Pigmentation Enhancer and with Potential Anti-Aging Properties
por: Jackson, Eileen, et al.
Publicado: (2019)

TrkA Co-Receptors: The Janus Face of TrkA?
por: Trouvilliez, Sarah, et al.
Publicado: (2023)

Appearance of aging signs in differently pigmented facial skin by a novel imaging system
por: Campiche, Remo, et al.
Publicado: (2018)

Gambogic acid protects LPS-induced apoptosis and inflammation in a cell model of neonatal pneumonia through the regulation of TrkA/Akt signaling pathway
por: Gao, Xu, et al.
Publicado: (2021)

Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies
por: Xhima, Kristiana, et al.
Publicado: (2021)

NGF – the TrkA to successful pain treatment
por: Kumar, Vinayak, et al.
Publicado: (2012)

Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity
por: Scarpi, D, et al.
Publicado: (2012)

Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity
por: Scarpi, D, et al.
Publicado: (2012)

Combinatorial Assembly of Small Molecules into Bivalent Antagonists of TrkC or TrkA Receptors
por: Brahimi, Fouad, et al.
Publicado: (2014)

Aging of the Hair Follicle Pigmentation System
por: Tobin, Desmond J
Publicado: (2009)

Development and Biological Characterization of a Novel Selective TrkA Agonist with Neuroprotective Properties against Amyloid Toxicity
por: Rogdakis, Thanasis, et al.
Publicado: (2022)

Transcytosis of TrkA leads to diversification of dendritic signaling endosomes
por: Barford, Kelly, et al.
Publicado: (2018)

NGF-stimulated retrograde transport of trkA in the mammalian nervous system
Publicado: (1995)

NGF Causes TrkA to Specifically Attract Microtubules to Lipid Rafts
por: Pryor, Shona, et al.
Publicado: (2012)

NGF FLIPs TrkA onto the death TRAIL in neuroblastoma cells
por: Ruggeri, P, et al.
Publicado: (2016)

A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria
por: Feinberg, Konstantin, et al.
Publicado: (2017)

Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles
por: Mason, Ashley J., et al.
Publicado: (2023)

Enhanced TrkA signaling impairs basal forebrain-dependent behavior
por: Calvo-Enrique, Laura, et al.
Publicado: (2023)

Sensory Neuron-Specific Deletion of Tropomyosin Receptor Kinase A (TrkA) in Mice Abolishes Osteoarthritis (OA) Pain via NGF/TrkA Intervention of Peripheral Sensitization
por: O-Sullivan, InSug, et al.
Publicado: (2022)

Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer’s disease
por: Xhima, K., et al.
Publicado: (2020)

Gating of the TrkH Ion Channel by its Associated RCK Protein, Trka
por: Cao, Yu, et al.
Publicado: (2013)

Systems Pharmacology of the NGF Signaling Through p75 and TrkA Receptors
por: Toni, T, et al.
Publicado: (2014)

Activation of the NGF/TrkA signaling pathway attenuates diabetic erectile dysfunction
por: Hou, Yi, et al.
Publicado: (2017)

Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling
por: Ye, Mengchen, et al.
Publicado: (2018)

Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation
por: Josephy-Hernandez, Sylvia, et al.
Publicado: (2019)

TrkA(+) Neurons Induce Pathologic Regeneration After Soft Tissue Trauma
por: Cherief, Masnsen, et al.
Publicado: (2022)

TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential
por: Zhang, Hanzhi, et al.
Publicado: (2020)

Uncoupling of Molecular Maturation from Peripheral Target Innervation in Nociceptors Expressing a Chimeric TrkA/TrkC Receptor
por: Gorokhova, Svetlana, et al.
Publicado: (2014)

Pincher, a pinocytic chaperone for nerve growth factor/TrkA signaling endosomes
por: Shao, Yufang, et al.
Publicado: (2002)

SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase
por: Marsh, H. Nicholas, et al.
Publicado: (2003)

Functional significance of nerve growth factor and its receptor (TrkA) in inflammatory arthritis
por: Raychaudhuri, Smriti K, et al.
Publicado: (2010)

Identification of a Novel Series of Potent TrkA Receptor Tyrosine Kinase Inhibitors
por: Raeppel, Stéphane L., et al.
Publicado: (2012)

Crystal Structure of a Two-Subunit TrkA Octameric Gating Ring Assembly
por: Deller, Marc C., et al.
Publicado: (2015)

Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents
por: Canu, Nadia, et al.
Publicado: (2017)

Hypofunctional TrkA Accounts for the Absence of Pain Sensitization in the African Naked Mole-Rat
por: Omerbašić, Damir, et al.
Publicado: (2016)

Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling
por: Wong, Hoi Leong Xavier, et al.
Publicado: (2019)

Characterization of KRC-108 as a TrkA Kinase Inhibitor with Anti-Tumor Effects
por: Lee, Hyo Jeong, et al.
Publicado: (2022)

TTF1 suppresses neuroblastoma growth and induces neuroblastoma differentiation by targeting TrkA and the miR-204/TrkB axis
por: Yang, Tianyou, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_47ujs0e2i32slhl36i8m9iop03