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Late-onset ulnar neuritis following treatment of lepromatous leprosy infection

Neuritis is a frequent complication of Myocobacteria leprae infection and treatment due to the variety of mechanisms through which it can occur. Not only can mycobacterial invasion into peripheral nerves directly cause damage and inflammation, but immune-mediated inflammatory episodes (termed lepros...

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Detalles Bibliográficos
Autores principales: Wellington, Trevor, Schofield, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715229/
https://www.ncbi.nlm.nih.gov/pubmed/31425515
http://dx.doi.org/10.1371/journal.pntd.0007684
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author Wellington, Trevor
Schofield, Christina
author_facet Wellington, Trevor
Schofield, Christina
author_sort Wellington, Trevor
collection PubMed
description Neuritis is a frequent complication of Myocobacteria leprae infection and treatment due to the variety of mechanisms through which it can occur. Not only can mycobacterial invasion into peripheral nerves directly cause damage and inflammation, but immune-mediated inflammatory episodes (termed leprosy reactions) can also manifest as neuritis at any point during infection. Treatment of leprosy reactions with thalidomide can also lead to neuritis due to an adverse drug effect. Neuritis can emerge years after initial diagnosis and treatment, although it is most frequently found at time of diagnosis or early into the treatment course. Treatment of neuritis is dependent on high-dose corticosteroid therapy as well as therapy for suspected underlying etiology. Here, we present a case of ulnar neuritis presenting in a patient with lepromatous leprosy four years after treatment of initial infection, with subsequent improvement after corticosteroid burst while maintained on thalidomide therapy.
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spelling pubmed-67152292019-09-10 Late-onset ulnar neuritis following treatment of lepromatous leprosy infection Wellington, Trevor Schofield, Christina PLoS Negl Trop Dis Research Article Neuritis is a frequent complication of Myocobacteria leprae infection and treatment due to the variety of mechanisms through which it can occur. Not only can mycobacterial invasion into peripheral nerves directly cause damage and inflammation, but immune-mediated inflammatory episodes (termed leprosy reactions) can also manifest as neuritis at any point during infection. Treatment of leprosy reactions with thalidomide can also lead to neuritis due to an adverse drug effect. Neuritis can emerge years after initial diagnosis and treatment, although it is most frequently found at time of diagnosis or early into the treatment course. Treatment of neuritis is dependent on high-dose corticosteroid therapy as well as therapy for suspected underlying etiology. Here, we present a case of ulnar neuritis presenting in a patient with lepromatous leprosy four years after treatment of initial infection, with subsequent improvement after corticosteroid burst while maintained on thalidomide therapy. Public Library of Science 2019-08-19 /pmc/articles/PMC6715229/ /pubmed/31425515 http://dx.doi.org/10.1371/journal.pntd.0007684 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Wellington, Trevor
Schofield, Christina
Late-onset ulnar neuritis following treatment of lepromatous leprosy infection
title Late-onset ulnar neuritis following treatment of lepromatous leprosy infection
title_full Late-onset ulnar neuritis following treatment of lepromatous leprosy infection
title_fullStr Late-onset ulnar neuritis following treatment of lepromatous leprosy infection
title_full_unstemmed Late-onset ulnar neuritis following treatment of lepromatous leprosy infection
title_short Late-onset ulnar neuritis following treatment of lepromatous leprosy infection
title_sort late-onset ulnar neuritis following treatment of lepromatous leprosy infection
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715229/
https://www.ncbi.nlm.nih.gov/pubmed/31425515
http://dx.doi.org/10.1371/journal.pntd.0007684
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