Cargando…
Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition
Nutrient excess, a major driver of obesity, diminishes hypothalamic responses to exogenously administered leptin, a critical hormone of energy balance. Here, we aimed to identify a physiological signal that arises from excess caloric intake and negatively controls hypothalamic leptin action. We foun...
Autores principales: | Kaneko, Kentaro, Fu, Yukiko, Lin, Hsiao-Yun, Cordonier, Elizabeth L., Mo, Qianxing, Gao, Yong, Yao, Ting, Naylor, Jacqueline, Howard, Victor, Saito, Kenji, Xu, Pingwen, Chen, Siyu S., Chen, Miao-Hsueh, Xu, Yong, Williams, Kevin W., Ravn, Peter, Fukuda, Makoto |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715359/ https://www.ncbi.nlm.nih.gov/pubmed/31403469 http://dx.doi.org/10.1172/JCI126107 |
Ejemplares similares
-
Rap1 in the VMH regulates glucose homeostasis
por: Kaneko, Kentaro, et al.
Publicado: (2021) -
Hypothalamic steroid receptor coactivator-2 regulates adaptations to fasting and overnutrition
por: Yang, Yongjie, et al.
Publicado: (2021) -
Novel Insights into How Overnutrition Disrupts the Hypothalamic Actions of Leptin
por: Fruhwürth, Stefanie, et al.
Publicado: (2018) -
Luciferase Reporter Mice for In Vivo Monitoring and Ex Vivo Assessment of Hypothalamic Signaling of Socs3 Expression
por: Cordonier, Elizabeth L, et al.
Publicado: (2019) -
Multi-generational Impact of Maternal Overnutrition/Obesity in the Sheep on the Neonatal Leptin Surge in Granddaughters
por: Shasa, Desiree R., et al.
Publicado: (2014)