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Autophagy–virus interplay in plants: from antiviral recognition to proviral manipulation

Autophagy is a conserved self‐cleaning and renewal system required for cellular homeostasis and stress tolerance. Autophagic processes are also implicated in the response to ‘non‐self’ such as viral pathogens, yet the functions and mechanisms of autophagy during plant virus infection have only recen...

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Autores principales: Kushwaha, Nirbhay Kumar, Hafrén, Anders, Hofius, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715616/
https://www.ncbi.nlm.nih.gov/pubmed/31397085
http://dx.doi.org/10.1111/mpp.12852
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author Kushwaha, Nirbhay Kumar
Hafrén, Anders
Hofius, Daniel
author_facet Kushwaha, Nirbhay Kumar
Hafrén, Anders
Hofius, Daniel
author_sort Kushwaha, Nirbhay Kumar
collection PubMed
description Autophagy is a conserved self‐cleaning and renewal system required for cellular homeostasis and stress tolerance. Autophagic processes are also implicated in the response to ‘non‐self’ such as viral pathogens, yet the functions and mechanisms of autophagy during plant virus infection have only recently started to be revealed. Compelling evidence now indicates that autophagy is an integral part of antiviral immunity in plants. It can promote the hypersensitive cell death response upon incompatible viral infections or mediate the selective elimination of entire particles and individual proteins from compatible viruses in a pathway similar to xenophagy in animals. Several viruses, however, have evolved measures to antagonize xenophagic degradation or utilize autophagy to suppress disease‐associated cell death and other defence pathways like RNA silencing. Here, we highlight the current advances and gaps in our understanding of the complex autophagy–virus interplay and its consequences for host immunity and viral pathogenesis in plants.
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spelling pubmed-67156162019-09-16 Autophagy–virus interplay in plants: from antiviral recognition to proviral manipulation Kushwaha, Nirbhay Kumar Hafrén, Anders Hofius, Daniel Mol Plant Pathol Microreviews Autophagy is a conserved self‐cleaning and renewal system required for cellular homeostasis and stress tolerance. Autophagic processes are also implicated in the response to ‘non‐self’ such as viral pathogens, yet the functions and mechanisms of autophagy during plant virus infection have only recently started to be revealed. Compelling evidence now indicates that autophagy is an integral part of antiviral immunity in plants. It can promote the hypersensitive cell death response upon incompatible viral infections or mediate the selective elimination of entire particles and individual proteins from compatible viruses in a pathway similar to xenophagy in animals. Several viruses, however, have evolved measures to antagonize xenophagic degradation or utilize autophagy to suppress disease‐associated cell death and other defence pathways like RNA silencing. Here, we highlight the current advances and gaps in our understanding of the complex autophagy–virus interplay and its consequences for host immunity and viral pathogenesis in plants. John Wiley and Sons Inc. 2019-08-09 /pmc/articles/PMC6715616/ /pubmed/31397085 http://dx.doi.org/10.1111/mpp.12852 Text en © 2019 The Authors. Molecular Plant Pathology published by British Society for Plant Pathology and John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Microreviews
Kushwaha, Nirbhay Kumar
Hafrén, Anders
Hofius, Daniel
Autophagy–virus interplay in plants: from antiviral recognition to proviral manipulation
title Autophagy–virus interplay in plants: from antiviral recognition to proviral manipulation
title_full Autophagy–virus interplay in plants: from antiviral recognition to proviral manipulation
title_fullStr Autophagy–virus interplay in plants: from antiviral recognition to proviral manipulation
title_full_unstemmed Autophagy–virus interplay in plants: from antiviral recognition to proviral manipulation
title_short Autophagy–virus interplay in plants: from antiviral recognition to proviral manipulation
title_sort autophagy–virus interplay in plants: from antiviral recognition to proviral manipulation
topic Microreviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715616/
https://www.ncbi.nlm.nih.gov/pubmed/31397085
http://dx.doi.org/10.1111/mpp.12852
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