Cargando…

CSL controls telomere maintenance and genome stability in human dermal fibroblasts

Genomic instability is a hallmark of cancer. Whether it also occurs in Cancer Associated Fibroblasts (CAFs) remains to be carefully investigated. Loss of CSL/RBP-Jκ, the effector of canonical NOTCH signaling with intrinsic transcription repressive function, causes conversion of dermal fibroblasts in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bottoni, Giulia, Katarkar, Atul, Tassone, Beatrice, Ghosh, Soumitra, Clocchiatti, Andrea, Goruppi, Sandro, Bordignon, Pino, Jafari, Paris, Tordini, Fabio, Lunardi, Thomas, Hoetzenecker, Wolfram, Neel, Victor, Lingner, Joachim, Paolo Dotto, G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715699/ https://www.ncbi.nlm.nih.gov/pubmed/31467287 http://dx.doi.org/10.1038/s41467-019-11785-7

Ejemplares similares

NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin
por: Katarkar, Atul, et al.
Publicado: (2020)

Convergent roles of ATF3 and CSL in chromatin control of cancer-associated fibroblast activation
por: Kim, Dong Eun, et al.
Publicado: (2017)

Autophagy Controls CSL/RBPJκ Stability through a p62/SQSTM1-Dependent Mechanism
por: Goruppi, Sandro, et al.
Publicado: (2018)

Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation
por: Procopio, Maria-Giuseppina, et al.
Publicado: (2015)

The ULK3 kinase is a determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome
por: Goruppi, Sandro, et al.
Publicado: (2023)

PDCD4 is a CSL associated protein with a transcription repressive function in cancer associated fibroblast activation
por: Jo, Seung-Hee, et al.
Publicado: (2016)

Dualism of FGF and TGF-β Signaling in Heterogeneous Cancer-Associated Fibroblast Activation with ETV1 as a Critical Determinant
por: Bordignon, Pino, et al.
Publicado: (2019)

The human telomeric proteome during telomere replication
por: Lin, Chih-Yi Gabriela, et al.
Publicado: (2021)

Sustained androgen receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis
por: Ma, Min, et al.
Publicado: (2020)

Fungal CSL transcription factors
por: Převorovský, Martin, et al.
Publicado: (2007)

Androgen receptor is a determinant of melanoma targeted drug resistance
por: Samarkina, Anastasia, et al.
Publicado: (2023)

HSD17B7 gene in self‐renewal and oncogenicity of keratinocytes from Black versus White populations
por: Xu, Xiaoying, et al.
Publicado: (2021)

RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops
por: Feretzaki, Marianna, et al.
Publicado: (2020)

Clinical Pharmacokinetics and Pharmacodynamics of CSL112
por: Ortega-Paz, Luis, et al.
Publicado: (2023)

TFIIH moonlighting at telomeres
por: Glousker, Galina, et al.
Publicado: (2022)

ALICE HMPID Csl photocathode coating station
Publicado: (2003)

Dissipative Continuous Spontaneous Localization (CSL) model
por: Smirne, Andrea, et al.
Publicado: (2015)

TERRA: telomeric repeat-containing RNA
por: Luke, Brian, et al.
Publicado: (2009)

Fission Yeast CSL Proteins Function as Transcription Factors
por: Oravcová, Martina, et al.
Publicado: (2013)

Dishevelled limits Notch signalling through inhibition of CSL
por: Collu, Giovanna M., et al.
Publicado: (2012)

Visualizing cellular heterogeneity by quantifying the dynamics of MAPK activity in live mammalian cells with synthetic fluorescent biosensors
por: Ma, Min, et al.
Publicado: (2020)

The THO complex counteracts TERRA R-loop-mediated telomere fragility in telomerase(+) cells and telomeric recombination in ALT(+) cells
por: Fernandes, Rita Valador, et al.
Publicado: (2023)

Transformation-induced stress at telomeres is counteracted through changes in the telomeric proteome including SAMHD1
por: Majerska, Jana, et al.
Publicado: (2018)

Expression profiling and integrative analysis of the CESA/CSL superfamily in rice
por: Wang, Lingqiang, et al.
Publicado: (2010)

Identification of Novel Targets of CSL-Dependent Notch Signaling in Hematopoiesis
por: Hamidi, Habib, et al.
Publicado: (2011)

Dissecting and Circumventing the Requirement for RAM in CSL-Dependent Notch Signaling
por: Johnson, Scott E., et al.
Publicado: (2012)

A proposal for the experimental detection of CSL induced random walk
por: Bera, Sayantani, et al.
Publicado: (2015)

Instrument Pointer Recognition Scheme Based on Improved CSL Algorithm
por: Liu, Hailong, et al.
Publicado: (2022)

In-Silico Structural and Functional Characterization of a V. cholerae O395 Hypothetical Protein Containing a PDZ1 and an Uncommon Protease Domain
por: Dutta, Avirup, et al.
Publicado: (2013)

Antiatherosclerotic Effects of CSL112 Mediated by Enhanced Cholesterol Efflux Capacity
por: Kingwell, Bronwyn A., et al.
Publicado: (2022)

OptIC-Notch reveals mechanism that regulates receptor interactions with CSL
por: Townson, Jonathan M., et al.
Publicado: (2023)

Molecular basis of telomere syndrome caused by CTC1 mutations
por: Chen, Liuh-Yow, et al.
Publicado: (2013)

TERRA Promotes Telomere Shortening through Exonuclease 1–Mediated Resection of Chromosome Ends
por: Pfeiffer, Verena, et al.
Publicado: (2012)

Fission Yeast CSL Transcription Factors: Mapping Their Target Genes and Biological Roles
por: Převorovský, Martin, et al.
Publicado: (2015)

Activation of the Notch Signaling Pathway In Vivo Elicits Changes in CSL Nuclear Dynamics
por: Gomez-Lamarca, Maria J., et al.
Publicado: (2018)

OPTHiS Identifies the Molecular Basis of the Direct Interaction between CSL and SMRT Corepressor
por: Kim, Gwang Sik, et al.
Publicado: (2018)

Correction to: Antiatherosclerotic Effects of CSL112 Mediated by Enhanced Cholesterol Efflux Capacity
Publicado: (2023)

ABC Transporter CslAB, a Stabilizer of ComCDE Signal in Streptococcus mutans
por: Liu, Tianlei, et al.
Publicado: (2015)

The CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathway
por: Contreras-Cornejo, Humberto, et al.
Publicado: (2016)

The telomeric DNA damage response occurs in the absence of chromatin decompaction
por: Vancevska, Aleksandra, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_s7dd68oqedih9d8ocmb51k9v5f